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Combination Immunotherapy with 4-1BBL and CTLA-4 Blockade for the Treatment of Prostate Cancer
Joint Authors
Hengchen, Zhu
Youlin, Kuang
Xiuheng, Liu
Li, Zhang
Xiaodong, Weng
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Immune regulation has been shown to be involved in the progressive growth of some murine tumours.
Interruption of immune regulatory pathways via activation of 4-1BB or cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) blockade appears to be a promising strategy for cancer immunotherapy.
In this study, we examined the effectiveness of 4-1BBL-expressing tumor cell vaccine in combination with CTLA-4 blockade on rejection of murine prostate cancer RM-1.
We found that the combination of both a vaccine consisting of 4-1BBL-expressing RM-1 cells and CTLA-4 blockade resulted in regression of RM-1 tumors and a significant increase in survival of the tumour cell recipients, compared to that of either treatment alone.
The combined vaccination resulted in higher CTL against RM-1 cells and increased secretion of IFN-γ, TNF-α, and IL-2 in the mix-cultured supernatant.
These results suggest that combining activation of 4-1BB and blockade of CTLA-4 may offer a new strategy for prostate cancer immunotherapy.
American Psychological Association (APA)
Youlin, Kuang& Li, Zhang& Xiaodong, Weng& Xiuheng, Liu& Hengchen, Zhu. 2012. Combination Immunotherapy with 4-1BBL and CTLA-4 Blockade for the Treatment of Prostate Cancer. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-472432
Modern Language Association (MLA)
Youlin, Kuang…[et al.]. Combination Immunotherapy with 4-1BBL and CTLA-4 Blockade for the Treatment of Prostate Cancer. Clinical and Developmental Immunology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-472432
American Medical Association (AMA)
Youlin, Kuang& Li, Zhang& Xiaodong, Weng& Xiuheng, Liu& Hengchen, Zhu. Combination Immunotherapy with 4-1BBL and CTLA-4 Blockade for the Treatment of Prostate Cancer. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-472432
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472432