The Effects of Old Age on Hepatic Stellate Cells
Joint Authors
McCuskey, Robert S.
Le Couteur, David G.
Cogger, Victoria C.
DeLeve, Laurie D.
Warren, Alessandra
Fraser, Robin
Source
Current Gerontology and Geriatrics Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aging is associated with marked changes in the hepatic sinusoid, yet the effect of old age on hepatic stellate cells (HSC) has not been well described.
Transmission electron microscopy and immunohistochemistry were used to study the effects of aging on HSC in livers from rats (3-4 mths versus 24–27 mths) and mice (2-3 mths versus 20–22 mths).
Desmin-positive HSC doubled in old age in both mice and rats.
Alpha-smooth muscle actin- (αSMA-) positive cells did not increase significantly and remained only a small percentage of desmin-positive cells.
Electron microscopy revealed that old age is associated with HSC that have a substantial increase in the number of lipid droplets which are larger in diameter.
There was also a marked increase of HSC that protruded into the sinusoidal lumen in old mice.
In conclusion, old age is associated with hyperplasia of HSC that are not activated and are engorged with lipid droplets.
American Psychological Association (APA)
Warren, Alessandra& Cogger, Victoria C.& Fraser, Robin& DeLeve, Laurie D.& McCuskey, Robert S.& Le Couteur, David G.. 2011. The Effects of Old Age on Hepatic Stellate Cells. Current Gerontology and Geriatrics Research،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-472489
Modern Language Association (MLA)
Warren, Alessandra…[et al.]. The Effects of Old Age on Hepatic Stellate Cells. Current Gerontology and Geriatrics Research No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-472489
American Medical Association (AMA)
Warren, Alessandra& Cogger, Victoria C.& Fraser, Robin& DeLeve, Laurie D.& McCuskey, Robert S.& Le Couteur, David G.. The Effects of Old Age on Hepatic Stellate Cells. Current Gerontology and Geriatrics Research. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-472489
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472489
