Exact Solution to the Extended Zwanzig Model for Quasi-Sigmoidal Chemically Induced Denaturation Profiles : Specific Heat and Configurational Entropy
Joint Authors
Aguilar-Pineda, G. E.
Olivares-Quiroz, L.
Source
International Journal of Statistical Mechanics
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Temperature and chemically induced denaturation comprise two of the most characteristic mechanisms to achieve the passage from the native state N to any of the unstructured states Dj in the denatured ensemble in proteins and peptides.
In this work we present a full analytical solution for the configurational partition function ?qs of a homopolymer chain poly-X in the extended Zwanzig model (EZM) for a quasisigmoidal denaturation profile.
This solution is built up from an EZM exact solution in the case where the fraction α of native contacts follows exact linear dependence on denaturant’s concentration ζ; thus an analytical solution for ?L in the case of an exact linear denaturation profile is also provided.
A recently established connection between the number ν of potential nonnative conformations per residue and temperature-independent helical propensity ω complements the model in order to identify specific proteinogenic poly-X chains, where X represents any of the twenty naturally occurring aminoacid residues.
From ?qs, equilibrium thermodynamic potentials like entropy ? and average internal energy 〈E〉 and thermodynamic susceptibilities like specific heat C? are calculated for poly-valine (poly-V) and poly-alanine (poly-A) chains.
The influence of the rate at which native contacts denature as function of ζ on thermodynamic stability is also discussed.
American Psychological Association (APA)
Aguilar-Pineda, G. E.& Olivares-Quiroz, L.. 2014. Exact Solution to the Extended Zwanzig Model for Quasi-Sigmoidal Chemically Induced Denaturation Profiles : Specific Heat and Configurational Entropy. International Journal of Statistical Mechanics،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-472496
Modern Language Association (MLA)
Aguilar-Pineda, G. E.& Olivares-Quiroz, L.. Exact Solution to the Extended Zwanzig Model for Quasi-Sigmoidal Chemically Induced Denaturation Profiles : Specific Heat and Configurational Entropy. International Journal of Statistical Mechanics No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-472496
American Medical Association (AMA)
Aguilar-Pineda, G. E.& Olivares-Quiroz, L.. Exact Solution to the Extended Zwanzig Model for Quasi-Sigmoidal Chemically Induced Denaturation Profiles : Specific Heat and Configurational Entropy. International Journal of Statistical Mechanics. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-472496
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472496