Nonalcoholic Fatty Liver Disease, Diabetes Mellitus and Cardiovascular Disease : Newer Data
Joint Authors
Migdalis, Ilias
Mavrogiannaki, A. N.
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Nonalcoholic fatty liver disease (NAFLD) is the most common, chronic liver disease worldwide.
Within this spectrum, steatosis alone is apparently benign, while nonalcoholic steatohepatitis may progress to cirrhosis and hepatocellular carcinoma.
NAFLD is strongly associated with obesity, dyslipidemia, type 2 diabetes mellitus, and cardiovascular disease.
The pathogenesis of hepatic steatosis is not clearly known, but its main characteristics are considered insulin resistance, mitochondrial dysfunction, increased free fatty acids reflux from adipose tissue to the liver, hepatocyte lipotoxicity, stimulation of chronic necroinflammation, and fibrogenic response.
With recent advances in technology, advanced imaging techniques provide important information for diagnosis.
There is a significant research effort in developing noninvasive monitoring of disease progression to fibrosis and response to therapy with potential novel biomarkers, in order to facilitate diagnosis for the detection of advanced cirrhosis and to minimize the need of liver biopsy.
The identification of NAFLD should be sought as part of the routine assessment of type 2 diabetics, as sought the microvascular complications and cardiovascular disease, because it is essential for the early diagnosis and proper intervention.
Diet, exercise training, and weight loss provide significant clinical benefits and must be considered of first line for treating NAFLD.
American Psychological Association (APA)
Mavrogiannaki, A. N.& Migdalis, Ilias. 2013. Nonalcoholic Fatty Liver Disease, Diabetes Mellitus and Cardiovascular Disease : Newer Data. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-472561
Modern Language Association (MLA)
Mavrogiannaki, A. N.& Migdalis, Ilias. Nonalcoholic Fatty Liver Disease, Diabetes Mellitus and Cardiovascular Disease : Newer Data. International Journal of Endocrinology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-472561
American Medical Association (AMA)
Mavrogiannaki, A. N.& Migdalis, Ilias. Nonalcoholic Fatty Liver Disease, Diabetes Mellitus and Cardiovascular Disease : Newer Data. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-472561
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472561