Association of P2Y12 Gene Promoter DNA Methylation with the Risk of Clopidogrel Resistance in Coronary Artery Disease Patients
Joint Authors
Fei, Xiaohong
Tong, Maoqing
Xu, Jin
Song, Haojun
Wang, Yaqing
Li, Xiaojing
Chen, Xiaomin
Liu, Yahui
Wang, Jian
Zhong, Jinyan
Cui, Hanbin
Zheng, Wenyuan
Lin, Shaoyi
Liu, Junsong
Du, Weiping
Yu, Qinglin
Zhang, Lulu
Su, Jia
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Clopidogrel inhibits the ADP receptor P2Y12 to keep down the platelet aggregation.
The goal of our study is to investigate the contribution of P2Y12 promoter DNA methylation to the risk of clopidogrel resistance (CR).
Methods.
The platelet functions were measured by the VerifyNow P2Y12 assay.
Applying the bisulfite pyrosequencing technology, DNA methylation levels of two CpG dinucleotides on P2Y12 promoter were tested among 49 CR cases and 57 non-CR controls.
We also investigated the association among P2Y12 DNA methylation, various biochemical characteristics, and CR.
Result.
Lower methylation of two CpGs indicated the poorer clopidogrel response (CpG1, P=0.009; CpG2, P=0.022) in alcohol abusing status.
Meanwhile CpG1 methylation was inversely correlated with CR in smoking patients (P=0.026) and in subgroup of Albumin < 35 (P=0.002).
We observed that the level of DNA methylation might be affected by some clinical markers, such as TBIL, LEVF, Albumin, AST.
The results also showed that the quantity of stent, fasting blood-glucose, and lower HbAC1 were the predictors of CR.
Conclusions.
The evidence from our study indicates that P2Y12 methylation may bring new hints to elaborate the pathogenesis of CR.
American Psychological Association (APA)
Su, Jia& Li, Xiaojing& Yu, Qinglin& Liu, Yahui& Wang, Yaqing& Song, Haojun…[et al.]. 2014. Association of P2Y12 Gene Promoter DNA Methylation with the Risk of Clopidogrel Resistance in Coronary Artery Disease Patients. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-472574
Modern Language Association (MLA)
Su, Jia…[et al.]. Association of P2Y12 Gene Promoter DNA Methylation with the Risk of Clopidogrel Resistance in Coronary Artery Disease Patients. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-472574
American Medical Association (AMA)
Su, Jia& Li, Xiaojing& Yu, Qinglin& Liu, Yahui& Wang, Yaqing& Song, Haojun…[et al.]. Association of P2Y12 Gene Promoter DNA Methylation with the Risk of Clopidogrel Resistance in Coronary Artery Disease Patients. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-472574
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472574