Promotion of the Toxic Action of Cyclophosphamide by Digestive Tract Luminal Ammonia in Rats
Joint Authors
Schäfer, Timur V.
Rejniuk, Vladimir L.
Ivnitsky, Jury Ju.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-14
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
To estimate the influence of the digestive tract luminal ammonia pool on acute toxic effects of cyclophosphamide, the dynamics of blood ammonia, glutamine and urea level, symptoms of toxic action and the survival time have been studied in rats, intraperitoneally treated with cyclophosphamide, at the background of the gavage with non-lethal dose of ammonium acetate (12 mmol/kg, i.e., 0.35 LD50).
Ammonium acetate enhanced the hyperammonaemic action of cyclophosphamide while promoting its lethal action: the mean survival time decreased 1.5, 2.1, 2.8, or 6.1 times at the background of cyclophosphamide i/p doses 200, 600, 1000, or 1400 mg/kg, respectively.
Animals exposed to the combination of toxicants, manifested symptoms which were characteristic of the effect of lethal doses of ammonia salts.
These data provide the evidence of the detrimental role of gastrointestinal luminal ammonia in the acute high-dose cyclophosphamide toxicity.
American Psychological Association (APA)
Ivnitsky, Jury Ju.& Schäfer, Timur V.& Rejniuk, Vladimir L.. 2011. Promotion of the Toxic Action of Cyclophosphamide by Digestive Tract Luminal Ammonia in Rats. ISRN Toxicology،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-472581
Modern Language Association (MLA)
Ivnitsky, Jury Ju.…[et al.]. Promotion of the Toxic Action of Cyclophosphamide by Digestive Tract Luminal Ammonia in Rats. ISRN Toxicology No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-472581
American Medical Association (AMA)
Ivnitsky, Jury Ju.& Schäfer, Timur V.& Rejniuk, Vladimir L.. Promotion of the Toxic Action of Cyclophosphamide by Digestive Tract Luminal Ammonia in Rats. ISRN Toxicology. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-472581
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472581