Enhanced Inflammatory Activity of Endometriotic Lesions from the Rectovaginal Septum

Joint Authors

Mueller, Michael D.
McKinnon, Brett D.
Bertschi, Dominic
Evers, Jakob
Bersinger, Nick A.

Source

Mediators of Inflammation

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-12-28

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Diseases

Abstract EN

Endometriosis is characterised by the growth of ectopic lesions at multiple locations outside the uterine cavity and may be considered a collection of distinct but related conditions.

The exact aetiology of endometriosis is still not clear although a role for inflammation is increasingly accepted.

We therefore investigated the inflammatory activity of eutopic tissue and that of the matching ectopic lesions from different locations by measuring the genetic expression of inflammatory chemokines and cytokines.

The gene expression in matching eutopic and ectopic tissue was compared, as was the gene expression in lesions from different locations.

A significantly higher mRNA expression of the chemokines ENA-78 and RANTES and the cytokines IL-6 and TNFα was observed in endometriotic lesions of the rectovaginal septum (RVS) compared to that of matching eutopic tissue.

Comparisons across lesion locations showed a significantly higher expression of IL-6 and TNFα in the RVS compared to lesions from either the ovaries or the peritoneum.

These results show that the production of some inflammatory chemokines and cytokines is significantly increased in the ectopic endometrial tissue compared to matching eutopic tissue.

Furthermore, IL-6 and TNFα are produced in significantly higher quantities in RVS lesions compared to other lesions.

American Psychological Association (APA)

Bertschi, Dominic& McKinnon, Brett D.& Evers, Jakob& Bersinger, Nick A.& Mueller, Michael D.. 2013. Enhanced Inflammatory Activity of Endometriotic Lesions from the Rectovaginal Septum. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-472587

Modern Language Association (MLA)

Bertschi, Dominic…[et al.]. Enhanced Inflammatory Activity of Endometriotic Lesions from the Rectovaginal Septum. Mediators of Inflammation No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-472587

American Medical Association (AMA)

Bertschi, Dominic& McKinnon, Brett D.& Evers, Jakob& Bersinger, Nick A.& Mueller, Michael D.. Enhanced Inflammatory Activity of Endometriotic Lesions from the Rectovaginal Septum. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-472587

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-472587