Novel Approach to Bile Duct Damage in Primary Biliary Cirrhosis : Participation of Cellular Senescence and Autophagy
Joint Authors
Sasaki, Motoko
Nakanuma, Yasuni
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Primary biliary cirrhosis (PBC) is characterized by antimitochondrial autoantibodies (AMAs) in patients' sera and histologically by chronic nonsuppurative destructive cholangitis in small bile ducts, eventually followed by extensive bile duct loss and biliary cirrhosis.
The autoimmune-mediated pathogenesis of bile duct lesions, including the significance of AMAs, triggers of the autoimmune process, and so on remain unclear.
We have reported that cellular senescence in biliary epithelial cells (BECs) may be involved in bile duct lesions and that autophagy may precede the process of biliary epithelial senescence in PBC.
Interestingly, BECs in damaged bile ducts show characteristicsof cellular senescence and autophagy in PBC.
A suspected causative factor of biliary epithelial senescence is oxidative stress.
Furthermore, senescent BECs may modulate the microenvironment around bile ducts by expressing various chemokines and cytokines called senescence-associated secretory phenotypes and contribute to the pathogenesis in PBC.
American Psychological Association (APA)
Sasaki, Motoko& Nakanuma, Yasuni. 2011. Novel Approach to Bile Duct Damage in Primary Biliary Cirrhosis : Participation of Cellular Senescence and Autophagy. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-472685
Modern Language Association (MLA)
Sasaki, Motoko& Nakanuma, Yasuni. Novel Approach to Bile Duct Damage in Primary Biliary Cirrhosis : Participation of Cellular Senescence and Autophagy. International Journal of Hepatology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-472685
American Medical Association (AMA)
Sasaki, Motoko& Nakanuma, Yasuni. Novel Approach to Bile Duct Damage in Primary Biliary Cirrhosis : Participation of Cellular Senescence and Autophagy. International Journal of Hepatology. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-472685
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472685