Controversies Surrounding the Potential Use of Histone Deacetylase Inhibitors for the Treatment of Asthma
Joint Authors
Royce, Simon G.
Ververis, Katherine
Karagiannis, Tom C.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Management of asthma with long-acting β2-adrenergic receptor agonists and corticosteroids is exceptionally effective for the majority of asthma patients.
However, corticosteroid insensitivity or resistance remains a significant clinical problem for a significant proportion of patients, requiring the investigation of new potential therapeutics for asthma.
Histone deacetylase inhibitors represent a different class of compounds that have been evaluated for their potential antiasthmatic effects.
Although accumulating evidence is indicating beneficial effects in rodent models of allergic airways disease, the potential use of histone deacetylase inhibitors in asthma remains controversial given their mechanisms of action.
The aim of this paper is to provide an overview of histone deacetylases and pharmacological modifiers of these enzymes.
The discussion represents a balanced account of the emerging evidence indicating the beneficial effects of histone deacetylase inhibitors in inflammatory lung diseases.
The potential problems associated with the use of this class of compounds in asthma are also carefully considered.
American Psychological Association (APA)
Royce, Simon G.& Ververis, Katherine& Karagiannis, Tom C.. 2012. Controversies Surrounding the Potential Use of Histone Deacetylase Inhibitors for the Treatment of Asthma. ISRN Pulmonology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-472690
Modern Language Association (MLA)
Royce, Simon G.…[et al.]. Controversies Surrounding the Potential Use of Histone Deacetylase Inhibitors for the Treatment of Asthma. ISRN Pulmonology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-472690
American Medical Association (AMA)
Royce, Simon G.& Ververis, Katherine& Karagiannis, Tom C.. Controversies Surrounding the Potential Use of Histone Deacetylase Inhibitors for the Treatment of Asthma. ISRN Pulmonology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-472690
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472690