Oxidative Stress and Free-Radical Oxidation in BCG Granulomatosis Development
Joint Authors
Menshchikova, Elena
Potapova, Oksana
Tkachev, Victor
Zenkov, Nikolay
Cherdantseva, Liliya
Shkurupiy, Vyacheslav A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Background.
Little is known about the role of free-radical and oxidative stress signaling in granuloma maturation and resolution.
We aimed to study the activity of free-radical oxidation processes in the dynamics of BCG-induced generalized granulomatosis in mice.
Methods.
Chronic granulomatous inflammation was induced in male BALB/c mice by intravenously injecting the BCG vaccine, and the production of oxidative stress (activity of free-radical oxidation processes) and histological changes in the lungs, liver, and peritoneal exudate were measured 3, 30, 60, and 90 days after infection.
Results.
The tuberculous granuloma numerical density and diameter continuously increased from day 30 to day 90, and the macrophage content within the granulomas progressively diminished with a concomitant elevation in the number of epithelioid cells.
The activity of the free-radical oxidation processes in the liver (i.e., the intensity of the homogenate chemiluminescence) reached a maximum at postinfection day 60 and subsequently began to decrease.
The peak generation of reactive oxygen species by phagocytes in the peritoneal exudate (measured using flow cytometry) was also shifted in time and fell on day 30.
Conclusions.
The rise in the steady-state concentration of H2O2 in the liver of mice with BCG-induced granulomatosis is not related to local H2O2 production by phagocytes, and a decrease in the severity of generalized inflammation precedes the resolution of local inflammation.
American Psychological Association (APA)
Menshchikova, Elena& Zenkov, Nikolay& Tkachev, Victor& Potapova, Oksana& Cherdantseva, Liliya& Shkurupiy, Vyacheslav A.. 2013. Oxidative Stress and Free-Radical Oxidation in BCG Granulomatosis Development. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-472717
Modern Language Association (MLA)
Menshchikova, Elena…[et al.]. Oxidative Stress and Free-Radical Oxidation in BCG Granulomatosis Development. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-472717
American Medical Association (AMA)
Menshchikova, Elena& Zenkov, Nikolay& Tkachev, Victor& Potapova, Oksana& Cherdantseva, Liliya& Shkurupiy, Vyacheslav A.. Oxidative Stress and Free-Radical Oxidation in BCG Granulomatosis Development. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-472717
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472717