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Profile of a Serial Killer : Cellular and Molecular Approaches to Study Individual Cytotoxic T-Cells following Therapeutic Vaccination
Joint Authors
Speiser, Daniel E.
Rufer, Nathalie
Wieckowski, Sébastien
Baumgaertner, Petra
Iancu, Emanuela M.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-14
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
T-cell vaccination may prevent or treat cancer and infectious diseases, but further progress is required to increase clinical efficacy.
Step-by-step improvements of T-cell vaccination in phase I/II clinical studies combined with very detailed analysis of T-cell responses at the single cell level are the strategy of choice for the identification of the most promising vaccine candidates for testing in subsequent large-scale phase III clinical trials.
Major aims are to fully identify the most efficient T-cells in anticancer therapy, to characterize their TCRs, and to pinpoint the mechanisms of T-cell recruitment and function in well-defined clinical situations.
Here we discuss novel strategies for the assessment of human T-cell responses, revealing in part unprecedented insight into T-cell biology and novel structural principles that govern TCR-pMHC recognition.
Together, the described approaches advance our knowledge of T-cell mediated-protection from human diseases.
American Psychological Association (APA)
Iancu, Emanuela M.& Baumgaertner, Petra& Wieckowski, Sébastien& Speiser, Daniel E.& Rufer, Nathalie. 2010. Profile of a Serial Killer : Cellular and Molecular Approaches to Study Individual Cytotoxic T-Cells following Therapeutic Vaccination. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-21.
https://search.emarefa.net/detail/BIM-472722
Modern Language Association (MLA)
Iancu, Emanuela M.…[et al.]. Profile of a Serial Killer : Cellular and Molecular Approaches to Study Individual Cytotoxic T-Cells following Therapeutic Vaccination. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-21.
https://search.emarefa.net/detail/BIM-472722
American Medical Association (AMA)
Iancu, Emanuela M.& Baumgaertner, Petra& Wieckowski, Sébastien& Speiser, Daniel E.& Rufer, Nathalie. Profile of a Serial Killer : Cellular and Molecular Approaches to Study Individual Cytotoxic T-Cells following Therapeutic Vaccination. Journal of Biomedicine and Biotechnology. 2010. Vol. 2011, no. 2011, pp.1-21.
https://search.emarefa.net/detail/BIM-472722
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472722