Fibroblast Growth Factor-2 and the HIV-1 Tat Protein Synergize in Promoting Bcl-2 Expression and Preventing Endothelial Cell Apoptosis : Implications for the Pathogenesis of AIDS-Associated Kaposi's Sarcoma
Joint Authors
Bellino, Stefania
Ensoli, Barbara
Palladino, Clelia
Sgadari, Cecilia
Taddeo, Brunella
Toschi, Elena
Barillari, Giovanni
Source
International Journal of Vascular Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Kaposi's sarcoma (KS) is a vascular tumor frequently occurring in Human Immunodeficiency Virus- (HIV-) 1-infected individuals.
Our previous work indicated that the angiogenic fibroblast growth factor (FGF)-2 and the Tat protein of HIV-1, both expressed in KS lesions of HIV-infected patients, synergize at inducing angioproliferative, KS-like lesions in mice.
Here we show that the development of angioproliferative lesions promoted in mice by combined Tat and FGF-2 associates with an increase in the levels of expression of the antiapoptotic Bcl-2 protein.
Upregulation of Bcl-2 expression by combined FGF-2 and Tat occurs also in vitro, and this protects human primary endothelial cells from programmed cell death.
As Bcl-2 is expressed in human KS lesions in a fashion paralleling the progression of the disease, these findings suggest a molecular mechanism by which Tat and FGF-2 cooperate in KS maintenance and progression in HIV-infected individuals.
American Psychological Association (APA)
Sgadari, Cecilia& Barillari, Giovanni& Palladino, Clelia& Bellino, Stefania& Taddeo, Brunella& Toschi, Elena…[et al.]. 2011. Fibroblast Growth Factor-2 and the HIV-1 Tat Protein Synergize in Promoting Bcl-2 Expression and Preventing Endothelial Cell Apoptosis : Implications for the Pathogenesis of AIDS-Associated Kaposi's Sarcoma. International Journal of Vascular Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-472738
Modern Language Association (MLA)
Sgadari, Cecilia…[et al.]. Fibroblast Growth Factor-2 and the HIV-1 Tat Protein Synergize in Promoting Bcl-2 Expression and Preventing Endothelial Cell Apoptosis : Implications for the Pathogenesis of AIDS-Associated Kaposi's Sarcoma. International Journal of Vascular Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-472738
American Medical Association (AMA)
Sgadari, Cecilia& Barillari, Giovanni& Palladino, Clelia& Bellino, Stefania& Taddeo, Brunella& Toschi, Elena…[et al.]. Fibroblast Growth Factor-2 and the HIV-1 Tat Protein Synergize in Promoting Bcl-2 Expression and Preventing Endothelial Cell Apoptosis : Implications for the Pathogenesis of AIDS-Associated Kaposi's Sarcoma. International Journal of Vascular Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-472738
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472738