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The Breakage-Fusion-Bridge Cycle Producing MLL Amplification in a Case of Myelodysplastic Syndrome
Joint Authors
Campbell, Lynda J.
MacKinnon, Ruth N.
Ta, Lan
Mercer, Bruce
Zordan, Adrian
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Telomere loss may lead to chromosomal instability via the breakage-fusion-bridge (BFB) cycle which can result in genetic amplification and the formation of ring and dicentric chromosomes.
This cycle continues until stable chromosomes are formed.
The case of a 72-year-old female with refractory anaemia with excess blasts type 2 illustrates these events.
Conventional cytogenetics produced a complex karyotype which included unstable abnormalities of chromosomes 11, 12, and 15.
Fluorescence in situ hybridization (FISH) analyses including multicolor-FISH (M-FISH) and multicolor-banding (M-BAND) revealed multiple clonal populations with 5 copies of MLL on either a ring chromosome composed entirely of chromosome 11 material or a derivative chromosome composed of chromosomes 11, 12, and 15.
The FISH results also clarified the likely evolution of the karyotypic complexity.
The simplest cell line contained a dic(12;15) in addition to copy number aberrations that are typical of MDS or AML.
As the disease progressed, a ring 11 was formed.
Subsequently, the ring 11 appears to have unwound and inserted itself into the dic(12;15) chromosome followed by an inversion of the derivative chromosome, producing a der(11;15;12).
Telomeric loss and BFB cycles appear to have played an important role in the chromosomal rearrangements and clonal evolution demonstrated in the karyotype.
American Psychological Association (APA)
Ta, Lan& Zordan, Adrian& Mercer, Bruce& Campbell, Lynda J.& MacKinnon, Ruth N.. 2013. The Breakage-Fusion-Bridge Cycle Producing MLL Amplification in a Case of Myelodysplastic Syndrome. Journal of Cancer Research،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-472748
Modern Language Association (MLA)
Ta, Lan…[et al.]. The Breakage-Fusion-Bridge Cycle Producing MLL Amplification in a Case of Myelodysplastic Syndrome. Journal of Cancer Research No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-472748
American Medical Association (AMA)
Ta, Lan& Zordan, Adrian& Mercer, Bruce& Campbell, Lynda J.& MacKinnon, Ruth N.. The Breakage-Fusion-Bridge Cycle Producing MLL Amplification in a Case of Myelodysplastic Syndrome. Journal of Cancer Research. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-472748
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472748