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Acylation of Chiral Alcohols : A Simple Procedure for Chiral GC Analysis
Joint Authors
Oromí-Farrús, Mireia
Torres, Mercè
Canela, Ramon
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The use of iodine as a catalyst and either acetic or trifluoroacetic acid as a derivatizing reagent for determining the enantiomeric composition of acyclic and cyclic aliphatic chiral alcohols was investigated.
Optimal conditions were selected according to the molar ratio of alcohol to acid, the reaction time, and the reaction temperature.
Afterwards, chiral stability of chiral carbons was studied.
Although no isomerization was observed when acetic acid was used, partial isomerization was detected with the trifluoroacetic acid.
A series of chiral alcohols of a widely varying structural type were then derivatized with acetic acid using the optimal conditions.
The resolution of the enantiomeric esters and the free chiral alcohols was measured using a capillary gas chromatograph equipped with a CP Chirasil-DEX CB column.
The best resolutions were obtained with 2-pentyl acetates (α=3.00) and 2-hexyl acetates (α=1.95).
This method provides a very simple and efficient experimental workup procedure for analyzing chiral alcohols by chiral-phase GC.
American Psychological Association (APA)
Oromí-Farrús, Mireia& Torres, Mercè& Canela, Ramon. 2012. Acylation of Chiral Alcohols : A Simple Procedure for Chiral GC Analysis. Journal of Analytical Methods in Chemistry،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-472759
Modern Language Association (MLA)
Oromí-Farrús, Mireia…[et al.]. Acylation of Chiral Alcohols : A Simple Procedure for Chiral GC Analysis. Journal of Analytical Methods in Chemistry No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-472759
American Medical Association (AMA)
Oromí-Farrús, Mireia& Torres, Mercè& Canela, Ramon. Acylation of Chiral Alcohols : A Simple Procedure for Chiral GC Analysis. Journal of Analytical Methods in Chemistry. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-472759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472759