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FOLDNA, a Web Server for Self-Assembled DNA Nanostructure Autoscaffolds and Autostaples
Joint Authors
Li, Can
Luo, Heng
Feng, Xiaolu
Li, Xingwang
Zhu, Jie
He, Lin
Zhou, Chensheng
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-25
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Engineering Sciences and Information Technology
Chemistry
Abstract EN
DNA self-assembly is a nanotechnology that folds DNA into desired shapes.
Self-assembled DNA nanostructures, also known as origami, are increasingly valuable in nanomaterial and biosensing applications.
Two ways to use DNA nanostructures in medicine are to form nanoarrays, and to work as vehicles in drug delivery.
The DNA nanostructures perform well as a biomaterial in these areas because they have spatially addressable and size controllable properties.
However, manually designing complementary DNA sequences for self-assembly is a technically demanding and time consuming task, which makes it advantageous for computers to do this job instead.
We have developed a web server, FOLDNA, which can automatically design 2D self-assembled DNA nanostructures according to custom pictures and scaffold sequences provided by the users.
It is the first web server to provide an entirely automatic design of self-assembled DNA nanostructure, and it takes merely a second to generate comprehensive information for molecular experiments including: scaffold DNA pathways, staple DNA directions, and staple DNA sequences.
This program could save as much as several hours in the designing step for each DNA nanostructure.
We randomly selected some shapes and corresponding outputs from our server and validated its performance in molecular experiments.
American Psychological Association (APA)
Zhou, Chensheng& Luo, Heng& Feng, Xiaolu& Li, Xingwang& Zhu, Jie& He, Lin…[et al.]. 2012. FOLDNA, a Web Server for Self-Assembled DNA Nanostructure Autoscaffolds and Autostaples. Journal of Nanotechnology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-472838
Modern Language Association (MLA)
Zhou, Chensheng…[et al.]. FOLDNA, a Web Server for Self-Assembled DNA Nanostructure Autoscaffolds and Autostaples. Journal of Nanotechnology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-472838
American Medical Association (AMA)
Zhou, Chensheng& Luo, Heng& Feng, Xiaolu& Li, Xingwang& Zhu, Jie& He, Lin…[et al.]. FOLDNA, a Web Server for Self-Assembled DNA Nanostructure Autoscaffolds and Autostaples. Journal of Nanotechnology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-472838
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472838