Surgical Options for Initially Unresectable Colorectal Liver Metastases
Joint Authors
Alexandrescu, Sorin Tiberiu
Popescu, Irinel
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-03
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Although the frontiers of liver resection for colorectal liver metastases have broadened in recent decades, approximately 75% of these patients present with unresectable metastases at the time of their diagnosis.
In the past, these patients underwent only palliative treatment, without the chance of a cure.
In the previous two decades, several therapeutic strategies have been developed that render resectable those metastases that were initially unresectable, thus offering the chance of long-term survival and even a cure to these patients.
The oncosurgical modalities that are available include liver resection following portal vein ligation/embolization, “two-stage” liver resection, one-stage ultrasonically guided liver resection, hepatectomy following conversion chemotherapy, and liver resection combined with thermal ablation.
Moreover, in recent years, certain authors have recommended the revisiting of the concept of liver transplantation in highly selected patients with unresectable colorectal liver metastases and favorable prognostic factors.
By employing such therapies, the number of patients with colorectal liver metastases who undergo a potentially curative treatment could increase to 40%.
The safety profile of these approaches is acceptable (morbidity rates as high as 45%, mortality rates of less than 5%).
Furthermore, the 5-year survival rates (approximately 30%) are significantly increased over those that were achieved with palliative treatment.
American Psychological Association (APA)
Popescu, Irinel& Alexandrescu, Sorin Tiberiu. 2012. Surgical Options for Initially Unresectable Colorectal Liver Metastases. HPB Surgery،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-472843
Modern Language Association (MLA)
Popescu, Irinel& Alexandrescu, Sorin Tiberiu. Surgical Options for Initially Unresectable Colorectal Liver Metastases. HPB Surgery No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-472843
American Medical Association (AMA)
Popescu, Irinel& Alexandrescu, Sorin Tiberiu. Surgical Options for Initially Unresectable Colorectal Liver Metastases. HPB Surgery. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-472843
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472843