The Effects of Addition of Mononucleotides on Sma nuc Endonuclease Activity
Joint Authors
Filimonova, Maria
Romanova, Julia
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Examination of the effects of mononucleotides on Sma nuc endonuclease originated from Gram negative bacterium Serratia marcescens displayed that any mononucleotide produced by Sma nuc during hydrolysis of DNA or RNA may regulate the enzyme activity affecting the RNase activity without pronounced influence on the activity towards DNA.
The type of carbohydrate residue in mononucleotides does not affect the regulation.
In contrast, the effects depend on the type of bases in nucleotides.
AMP or dAMP was classified as a competitive inhibitor of partial type.
GMP, UMP, and CMP were found to be uncompetitive inhibitors that suggest a specific site(s) for the nucleotide(s) binding in Sma nuc endonuclease.
American Psychological Association (APA)
Romanova, Julia& Filimonova, Maria. 2012. The Effects of Addition of Mononucleotides on Sma nuc Endonuclease Activity. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-472853
Modern Language Association (MLA)
Romanova, Julia& Filimonova, Maria. The Effects of Addition of Mononucleotides on Sma nuc Endonuclease Activity. The Scientific World Journal No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-472853
American Medical Association (AMA)
Romanova, Julia& Filimonova, Maria. The Effects of Addition of Mononucleotides on Sma nuc Endonuclease Activity. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-472853
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472853