Ginsenoside Rb1 Reduces Isoproterenol-Induced Cardiomyocytes Apoptosis In Vitro and In Vivo
Joint Authors
Lu, Yi-yu
Wang, Xiu-feng
Zhang, Tian-ling
Du, Jia
Liu, Xin-jun
Su, Shi-Bing
Zhou, Qian-mei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cardiomyocytes apoptosis can lead to heart failure.
Conventional and alternative drugs, such as Chinese herbal remedies, have been developed to target cardiomyoblast cells apoptosis.
In this study, we investigated the effects of ginsenoside Rb1 (Rb1), an active compound, which is isolated from Notoginseng and Ginseng on isoproterenol-(ISO-) induced apoptosis in rat cardiomyocytes and its mechanism in vivo and in vitro.
Rb1 reduced the ISO-induced apoptosis in rat cardiomyocytes and H9c2 cells.
The effect of Rb1 was significantly suppressed by H89 (inhibitor for PKA), but not by C-1 (inhibitor for PKC).
Based on in-cell blot analysis, the ISO-induced PKA and PKC expressions were decreased by Rb1, which was inhibited by H89, but not by C-1.
The expressions of caspase-3 and caspase-9 were decreased after treatment with both ISO and Rb1, but with no change for caspase-8.
Our results indicated that Rb1 reducing ISO-induced rat cardiomyocytes apoptosis may be involved in PKA and caspase-9 pathways.
American Psychological Association (APA)
Wang, Xiu-feng& Liu, Xin-jun& Zhou, Qian-mei& Du, Jia& Zhang, Tian-ling& Lu, Yi-yu…[et al.]. 2013. Ginsenoside Rb1 Reduces Isoproterenol-Induced Cardiomyocytes Apoptosis In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-472869
Modern Language Association (MLA)
Wang, Xiu-feng…[et al.]. Ginsenoside Rb1 Reduces Isoproterenol-Induced Cardiomyocytes Apoptosis In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-472869
American Medical Association (AMA)
Wang, Xiu-feng& Liu, Xin-jun& Zhou, Qian-mei& Du, Jia& Zhang, Tian-ling& Lu, Yi-yu…[et al.]. Ginsenoside Rb1 Reduces Isoproterenol-Induced Cardiomyocytes Apoptosis In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-472869
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472869