Retrospective Study of Japanese Patients with Schizophrenia Treated with Aripiprazole
Joint Authors
Sekido, Keiko
Kataoka, Mika
Yasuhara, Yuko
Tomotake, Masahito
Mifune, Kazushi
Locsin, Rozzano
Fuji, Syoko
Tanioka, Tetsuya
King, Beth
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aim.
The purpose of this retrospective study was to evaluate changes in clinical indicators which influence the quality of life (QOL) of patients with schizophrenia treated by antipsychotic therapy before and after switching to aripiprazole.
Methods.
A retrospective chart review of 27 patients diagnosed with schizophrenia and who were switched from one antipsychotic to aripiprazole was performed.
Clinical indicators about the daily dosage of antipsychotics and antiparkinsonian drugs, psychiatric condition, and glucose/lipid metabolism, clinical evaluation by nursing observation were used to measure the responsiveness of subjects to aripiprazole.
Results.
Of the 27 subjects, 14 responded to the switch to aripiprazole with significant improvement of the Brief Psychiatric Rating Scale (BPRS) score (P=0.04), significant decrease in dosage of antipsychotics in 71% of patients (P=0.03), and tendency toward reduction in dosage of antiparkinsonian drugs (P=0.07) and body mass index (BMI) (P=0.06).
However, 8 of 27 subjects had a significant increase in lipid levels after switching to aripiprazole (P=0.01).
Conclusion.
QOL for subjects who responded to the switch to aripiprazole improved as indicated by lower doses of antipsychotic and antiparkinson medications, improvement in BPRS score, and a decrease in BMI.
Results indicate little influence on patient's QOL.
American Psychological Association (APA)
Tanioka, Tetsuya& Fuji, Syoko& Kataoka, Mika& King, Beth& Tomotake, Masahito& Yasuhara, Yuko…[et al.]. 2012. Retrospective Study of Japanese Patients with Schizophrenia Treated with Aripiprazole. ISRN Nursing،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-472900
Modern Language Association (MLA)
Tanioka, Tetsuya…[et al.]. Retrospective Study of Japanese Patients with Schizophrenia Treated with Aripiprazole. ISRN Nursing No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-472900
American Medical Association (AMA)
Tanioka, Tetsuya& Fuji, Syoko& Kataoka, Mika& King, Beth& Tomotake, Masahito& Yasuhara, Yuko…[et al.]. Retrospective Study of Japanese Patients with Schizophrenia Treated with Aripiprazole. ISRN Nursing. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-472900
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472900