The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas
Joint Authors
Adamopoulos, Christos
Levidou, Georgia
El Habr, Elias A.
Saetta, Aggeliki A.
Korkolopoulou, Penelope
Piperi, Christina
Source
Neurology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Astrocytomas, the most common type of gliomas, and especially grade IV glioblastomas are “endowed” with strong proliferation and invasion potentials, high recurrence rate, and poor patients' prognosis.
Aberrant signaling of AKT-mTOR (mammalian target of rapamycin) has been implicated in carcinogenesis.
This paper is focused on the impact of deregulated AKT-mTOR signaling components in the clinical outcome and prognosis of human astrocytomas.
Current therapeutic targeting of astrocytomas with AKT-mTOR inhibitors in preclinical and clinical stage is also discussed, including future perspectives regarding the management of these devastating tumors.
American Psychological Association (APA)
El Habr, Elias A.& Adamopoulos, Christos& Levidou, Georgia& Saetta, Aggeliki A.& Korkolopoulou, Penelope& Piperi, Christina. 2012. The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas. Neurology Research International،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-472903
Modern Language Association (MLA)
El Habr, Elias A.…[et al.]. The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas. Neurology Research International No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-472903
American Medical Association (AMA)
El Habr, Elias A.& Adamopoulos, Christos& Levidou, Georgia& Saetta, Aggeliki A.& Korkolopoulou, Penelope& Piperi, Christina. The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas. Neurology Research International. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-472903
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472903