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No Evidence for Statin-induced Proteinuria in Healthy Volunteers as Assessed by Proteomic Analysis
Joint Authors
D'Haese, Patrick C.
Geryl, Hilde
Verhulst, Anja
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In clinical studies of statins (class of drugs lowering plasma cholesterol levels), transient low-molecular-weight proteinuria was observed.
The causes of statin-induced proteinuria in the patient background of those studies (cardiovascular and kidney disease) are multifactorial and, therefore, a matter of debate.
In light of this, it seemed interesting to investigate the effect of statins on the urinary protein concentration and proteome in healthy volunteers.
Six healthy volunteers were randomly treated with rosuvastatin (40 mg/day) or pravastatin (80 mg/day) in a double-blinded cross-over study.
Total urinary protein concentration and the concentration of albumin/retinol-binding protein were analysed, after which the urinary proteome was investigated.
From the results described in this study, it was concluded that statins do not induce major changes in the urinary protein concentration/proteome.
High variability in the baseline urinary proteome/proteins among volunteers, however, made it very difficult to find subtle (possibly isolated to individuals) effects of statins.
American Psychological Association (APA)
Verhulst, Anja& Geryl, Hilde& D'Haese, Patrick C.. 2011. No Evidence for Statin-induced Proteinuria in Healthy Volunteers as Assessed by Proteomic Analysis. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-472916
Modern Language Association (MLA)
Verhulst, Anja…[et al.]. No Evidence for Statin-induced Proteinuria in Healthy Volunteers as Assessed by Proteomic Analysis. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-472916
American Medical Association (AMA)
Verhulst, Anja& Geryl, Hilde& D'Haese, Patrick C.. No Evidence for Statin-induced Proteinuria in Healthy Volunteers as Assessed by Proteomic Analysis. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-472916
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472916