Protein-Protein Interactions Inferred from Domain-Domain Interactions in Genogroup II Genotype 4 Norovirus Sequences
Joint Authors
Huang, Chuan-Ching
Tang, Chuan Yi
Source
International Journal of Genomics
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Severe gastroenteritis and foodborne illness caused by Noroviruses (NoVs) during the winter are a worldwide phenomenon.
Vulnerable populations including young children and elderly and immunocompromised people often require hospitalization and may die.
However, no efficient vaccine for NoVs exists because of their variable genome sequences.
This study investigates the infection processes in protein-protein interactions between hosts and NoVs.
Protein-protein interactions were collected from related Pfam NoV domains.
The related Pfam domains were accumulated incrementally from the protein domain interaction database.
To examine the influence of domain intimacy, the 7 NoV domains were grouped by depth.
The number of domain-domain interactions increased exponentially as the depth increased.
Many protein-protein interactions were relevant; therefore, cloud techniques were used to analyze data because of their computational capacity.
The infection relationship between hosts and NoVs should be used in clinical applications and drug design.
American Psychological Association (APA)
Huang, Chuan-Ching& Tang, Chuan Yi. 2013. Protein-Protein Interactions Inferred from Domain-Domain Interactions in Genogroup II Genotype 4 Norovirus Sequences. International Journal of Genomics،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-472937
Modern Language Association (MLA)
Huang, Chuan-Ching& Tang, Chuan Yi. Protein-Protein Interactions Inferred from Domain-Domain Interactions in Genogroup II Genotype 4 Norovirus Sequences. International Journal of Genomics No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-472937
American Medical Association (AMA)
Huang, Chuan-Ching& Tang, Chuan Yi. Protein-Protein Interactions Inferred from Domain-Domain Interactions in Genogroup II Genotype 4 Norovirus Sequences. International Journal of Genomics. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-472937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472937