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Treatment Interruption after Pregnancy : Effects on Disease Progression and Laboratory Findings
Joint Authors
Mofenson, L. M.
LaRussa, P.
Mendez, H.
Diaz, C.
Hanson, C.
Lu, M.
Rich, K.
Thompson, B.
Meyer, W. A.
Tuomala, R. E.
Watts, D. H.
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To assess clinical progression and inflammatory markers among women stopping or continuing antiretroviral therapy (ART) after pregnancy.
Methods.
ART-naïve women with CD4+ lymphocyte counts >350 cells/uL initiating ART during pregnancy had clinical events and laboratory markers compared over one year postpartum between those stopping (n=59) or continuing (n=147) ART.
Results.
Slopes in CD4 count and HIV RNA did not differ between groups overall and in subsets of ZDV or combination therapy.
The hazard ratio (HR) of a new class B event was 2.09 (95% CI 0.79–5.58) among women stopping ART, 1.24 (0.31–4.95) in those stopping ZDV, and 2.93 (0.64–13.36) among those stopping combination therapy.
Women stopping ART had increased immune activation.
No significant differences were seen in C-reactive protein, lipids, leptin, or interleukin-6.
Conclusions.
While changes in CD4 and HIV RNA levels over one year were similar between women stopping or continuing ART postpartum, higher immune activation among women stopping therapy requires further study.
American Psychological Association (APA)
Watts, D. H.& Lu, M.& Thompson, B.& Tuomala, R. E.& Meyer, W. A.& Mendez, H.…[et al.]. 2009. Treatment Interruption after Pregnancy : Effects on Disease Progression and Laboratory Findings. Infectious Diseases in Obstetrics and Gynecology،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-472961
Modern Language Association (MLA)
Watts, D. H.…[et al.]. Treatment Interruption after Pregnancy : Effects on Disease Progression and Laboratory Findings. Infectious Diseases in Obstetrics and Gynecology No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-472961
American Medical Association (AMA)
Watts, D. H.& Lu, M.& Thompson, B.& Tuomala, R. E.& Meyer, W. A.& Mendez, H.…[et al.]. Treatment Interruption after Pregnancy : Effects on Disease Progression and Laboratory Findings. Infectious Diseases in Obstetrics and Gynecology. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-472961
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472961