Apoptotic Pathways in Pemphigus
Joint Authors
Jolly, Puneet
Rubenstein, David S.
Bektas, Meryem
Source
Dermatology Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Pemphigus is a group of human autoimmune blistering diseases of the skin in which autoantibodies to desmosome cadherins induce loss of cell-cell adhesion (acantholysis).
In addition to steric hindrance and activation of intracellular signaling, apoptosis has been suggested to contribute to the mechanism by which pathogenic IgG induces acantholysis.
We review the current literature examining the role of apoptosis in pemphigus.
Current data suggest that apoptosis is not required for blister induction, but that activation of proapoptotic proteins, including caspase cysteine proteinases, may sensitize cells to the acantholytic effects of pemphigus IgG.
American Psychological Association (APA)
Bektas, Meryem& Jolly, Puneet& Rubenstein, David S.. 2010. Apoptotic Pathways in Pemphigus. Dermatology Research and Practice،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-472979
Modern Language Association (MLA)
Bektas, Meryem…[et al.]. Apoptotic Pathways in Pemphigus. Dermatology Research and Practice No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-472979
American Medical Association (AMA)
Bektas, Meryem& Jolly, Puneet& Rubenstein, David S.. Apoptotic Pathways in Pemphigus. Dermatology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-472979
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472979