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Chromosomal Damage and Apoptosis in Exfoliated Buccal Cells from Individuals with Oral Cancer
Joint Authors
Oliveira, Márcio Campos
Meireles, José Roberto Cardoso
de Bragança Pereira, Carlos Alberto
Polpo de Campos, Adriano
Cerqueira, Eneida de Moraes Macílio
Dórea, Lavínia Tércia Magalhães
Lessa, Júlia Paula Ramos
Source
International Journal of Dentistry
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This study aimed to investigate cytological abnormalities indicative of chromosome damage (micronuclei) and apoptosis (karyorrhexis, pyknosis, and condensed chromatin) in exfoliated cells from the buccal mucosa of patients with oral cancer and control subjects.
The sample included twenty individuals with oral cancer and forty individuals with normal buccal mucosa.
Material was collected from the cheek epithelium in areas with lesions and areas without abnormalities.
A minimum of one thousand cells was analyzed.
Micronuclei were found significantly more frequently in cells collected from lesions than in cells from normal areas, independent of the presence/absence of cancer (P<0.0001).
They were also significantly more frequent in smokers and in mouthwash users (P<0.0001).
Apoptosis occurred significantly less frequently in individuals with oral cancer (P<0.0001).
These results show that oral cancer is associated with higher frequency of chromosomal damage and suggest that apoptosis is compromised in the buccal cells of individuals with this kind of neoplasia.
American Psychological Association (APA)
Dórea, Lavínia Tércia Magalhães& Meireles, José Roberto Cardoso& Lessa, Júlia Paula Ramos& Oliveira, Márcio Campos& de Bragança Pereira, Carlos Alberto& Polpo de Campos, Adriano…[et al.]. 2012. Chromosomal Damage and Apoptosis in Exfoliated Buccal Cells from Individuals with Oral Cancer. International Journal of Dentistry،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-473001
Modern Language Association (MLA)
Dórea, Lavínia Tércia Magalhães…[et al.]. Chromosomal Damage and Apoptosis in Exfoliated Buccal Cells from Individuals with Oral Cancer. International Journal of Dentistry No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-473001
American Medical Association (AMA)
Dórea, Lavínia Tércia Magalhães& Meireles, José Roberto Cardoso& Lessa, Júlia Paula Ramos& Oliveira, Márcio Campos& de Bragança Pereira, Carlos Alberto& Polpo de Campos, Adriano…[et al.]. Chromosomal Damage and Apoptosis in Exfoliated Buccal Cells from Individuals with Oral Cancer. International Journal of Dentistry. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-473001
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473001