Kainic Acid-Induced Neurodegenerative Model : Potentials and Limitations
Joint Authors
Zhang, Hong-Liang
Zhu, Jie
Luo, Qi
Zheng, Xiang-Yu
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Excitotoxicity is considered to be an important mechanism involved in various neurodegenerative diseases in the central nervous system (CNS) such as Alzheimer's disease (AD).
However, the mechanism by which excitotoxicity is implicated in neurodegenerative disorders remains unclear.
Kainic acid (KA) is an epileptogenic and neuroexcitotoxic agent by acting on specific kainate receptors (KARs) in the CNS.
KA has been extensively used as a specific agonist for ionotrophic glutamate receptors (iGluRs), for example, KARs, to mimic glutamate excitotoxicity in neurodegenerative models as well as to distinguish other iGluRs such as α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors and N-methyl-D-aspartate receptors.
Given the current knowledge of excitotoxicity in neurodegeneration, interventions targeted at modulating excitotoxicity are promising in terms of dealing with neurodegenerative disorders.
This paper summarizes the up-to-date knowledge of neurodegenerative studies based on KA-induced animal model, with emphasis on its potentials and limitations.
American Psychological Association (APA)
Zheng, Xiang-Yu& Zhang, Hong-Liang& Luo, Qi& Zhu, Jie. 2010. Kainic Acid-Induced Neurodegenerative Model : Potentials and Limitations. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-473004
Modern Language Association (MLA)
Zheng, Xiang-Yu…[et al.]. Kainic Acid-Induced Neurodegenerative Model : Potentials and Limitations. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-473004
American Medical Association (AMA)
Zheng, Xiang-Yu& Zhang, Hong-Liang& Luo, Qi& Zhu, Jie. Kainic Acid-Induced Neurodegenerative Model : Potentials and Limitations. Journal of Biomedicine and Biotechnology. 2010. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-473004
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473004