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Non-Cross Resistant Sequential Single Agent Chemotherapy in First-Line Advanced Non-Small Cell Lung Cancer Patients : Results of a Phase II Study
Joint Authors
van Klaveren, R. J.
Hoogsteden, Henk C.
Surmont, V.
Tan, K. Y.
Vernhout, R.
Schramel, F.
Aerts, Joachim G. J. V.
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
sequential chemotherapy can maintain dose intensity and preclude cumulative toxicity by increasing drug diversity.
Purpose.
to investigate the toxicity and efficacy of the sequential regimen of gemcitabine followed by paclitaxel in first line advanced stage non-small cell lung cancer (NSCLC) patients with good performance status (PS).
Patients and methods.
gemcitabine 1250 mg/m2 was administered on day 1 and 8 of course 1 and 2; Paclitaxel 150 mg/m2 on day 1 and 8 of course 3 and 4.
Primary endpoint was response rate (RR), secondary endpoints toxicity and time to progression (TTP).
Results.
Of the 21 patients (median age 56, range 38–80 years; 62% males, 38% females) 10% (2/21) had stage IIIB, 90% (19/21) stage IV, 15% PS 0, 85% PS 1.
20% of patients had a partial response, 30% stable disease, 50% progressive disease.
Median TTP was 12 weeks (range 6–52 weeks), median overall survival (OS) 8 months (range 1–27 months), 1-year survival was 33%.
One patient had grade 3 hematological toxicity, 2 patients a grade 3 peripheral neuropathy.
Conclusions.
sequential administration of gemcitabine followed by paclitaxel in first line treatment of advanced NSCLC had a favourable toxicity profile, a median TTP and OS comparable with other sequential trials and might, therefore, be a treatment option for NSCLC patients with high ERCC1 expression.
American Psychological Association (APA)
Surmont, V.& Aerts, Joachim G. J. V.& Tan, K. Y.& Schramel, F.& Vernhout, R.& Hoogsteden, Henk C.…[et al.]. 2009. Non-Cross Resistant Sequential Single Agent Chemotherapy in First-Line Advanced Non-Small Cell Lung Cancer Patients : Results of a Phase II Study. Journal of Oncology،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-473042
Modern Language Association (MLA)
Surmont, V.…[et al.]. Non-Cross Resistant Sequential Single Agent Chemotherapy in First-Line Advanced Non-Small Cell Lung Cancer Patients : Results of a Phase II Study. Journal of Oncology No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-473042
American Medical Association (AMA)
Surmont, V.& Aerts, Joachim G. J. V.& Tan, K. Y.& Schramel, F.& Vernhout, R.& Hoogsteden, Henk C.…[et al.]. Non-Cross Resistant Sequential Single Agent Chemotherapy in First-Line Advanced Non-Small Cell Lung Cancer Patients : Results of a Phase II Study. Journal of Oncology. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-473042
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473042