Gastric Carcinomas Localized to the Cardia
Joint Authors
Waldum, Helge L.
Fossmark, Reidar
Nordrum, Ivar S.
Bakkelund, Karin E.
Source
Gastroenterology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
Gastric adenocarcinomas localized to the cardia are increasing.
Enterochromaffin-like (ECL) cells play a role in gastric carcinogenesis in hypergastrinemia, and the use of proton pump inhibitors (PPI) leading to hypergastrinemia has increased considerably during the last decades.
We have examined cardia cancers for neuroendocrine and ECL cell differentiation.
Methods.
Thirty-two cardia cancers were examined by immunohistochemical labelling of chromogranin A (CgA), synaptophysin, serotonin, and histidine decarboxylase (HDC).
Information about PPI use was collected from the patient records.
Results.
In 15 of 32 tumours, there were positive signs for one or several neuroendocrine markers.
Five cases were CgA and serotonin positive; three of these carcinomas were also positive for HDC.
Three patients were long-term users of PPI, and two of these were immunoreactive for neuroendocrine markers.
Conclusions.
A high proportion of cardia cancers expressed neuroendocrine markers, but only few patients with cardia cancers were using PPI.
American Psychological Association (APA)
Bakkelund, Karin E.& Nordrum, Ivar S.& Fossmark, Reidar& Waldum, Helge L.. 2012. Gastric Carcinomas Localized to the Cardia. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-473066
Modern Language Association (MLA)
Bakkelund, Karin E.…[et al.]. Gastric Carcinomas Localized to the Cardia. Gastroenterology Research and Practice No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-473066
American Medical Association (AMA)
Bakkelund, Karin E.& Nordrum, Ivar S.& Fossmark, Reidar& Waldum, Helge L.. Gastric Carcinomas Localized to the Cardia. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-473066
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473066