T-Cell and Antibody Responses to Mycobacterial Antigens in Tuberculin Skin-Test-Positive Bos indicus and Bos taurus Cattle in Ethiopia
Joint Authors
Ameni, Gobena
Lyashchenko, Konstantin P.
Vordermeier, Martin
Cockle, Paul
Source
Veterinary Medicine International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Higher IFN-γ responses to mycobacterial antigens were observed in Bos taurus (Holsteins) than in Bos indicus (Zebu) cattle which could due to differences in antigen recognition profiles between the two breeds.
The present study was conducted to evaluate mycobacterial antigen recognition profiles of the two breeds.
Twenty-three mycobacterial antigens were tested on 46 skin test positive (24 Zebu and 22 Holstein) using enzyme-linked immunospot assay (ELISPOT) and multiple antigen print immunoassay (MAPIA).
Herds from which the study cattle obtained were tested for Fasciola antibody.
The T cells from both breeds recognized most of the mycobacterial antigens at lower and comparable frequencies.
However, antigens such as CFP-10, ESAT-6, Rv0287, Rv0288, MPB87, Acr-2, Rv3616c, and Rv3879c were recognized at higher frequencies in zebu while higher frequencies of T cell responses were observed to Hsp65 in both breeds.
Furthermore, comparable antibody responses were observed in both breeds; MPB83 being the sero-dominant antigen in both breeds.
The prevalence of Fasciola antibody was 81% and similar in both breeds.
This piece of work could not lead to a definitive conclusion if there are differences in mycobacterial recognition profiles between the two breeds warranting for further similar studies using sound sample size from the two breeds.
American Psychological Association (APA)
Ameni, Gobena& Cockle, Paul& Lyashchenko, Konstantin P.& Vordermeier, Martin. 2012. T-Cell and Antibody Responses to Mycobacterial Antigens in Tuberculin Skin-Test-Positive Bos indicus and Bos taurus Cattle in Ethiopia. Veterinary Medicine International،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-473070
Modern Language Association (MLA)
Ameni, Gobena…[et al.]. T-Cell and Antibody Responses to Mycobacterial Antigens in Tuberculin Skin-Test-Positive Bos indicus and Bos taurus Cattle in Ethiopia. Veterinary Medicine International No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-473070
American Medical Association (AMA)
Ameni, Gobena& Cockle, Paul& Lyashchenko, Konstantin P.& Vordermeier, Martin. T-Cell and Antibody Responses to Mycobacterial Antigens in Tuberculin Skin-Test-Positive Bos indicus and Bos taurus Cattle in Ethiopia. Veterinary Medicine International. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-473070
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473070