Comparative Genomic Hybridization Selection of Blastocysts for Repeated Implantation Failure Treatment : A Pilot Study
Joint Authors
Bono, Sara
Minasi, Maria Giulia
Spizzichino, Letizia
Ruberti, Alessandra
Lobascio, Anna Maria
Biricik, Anil
Tesarik, Jan
Greco, Alessia
Fiorentino, Francesco
Greco, Pierfrancesco
Greco, Ermanno
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The aim of this study is to determine if the use of preimplantation genetic screening (PGS) by array comparative genomic hybridization (array CGH) and transfer of a single euploid blastocyst in patients with repeated implantation failure (RIF) can improve clinical results.
Three patient groups are compared: 43 couples with RIF for whom embryos were selected by array CGH (group RIF-PGS), 33 couples with the same history for whom array CGH was not performed (group RIF NO PGS), and 45 good prognosis infertile couples with array CGH selected embryos (group NO RIF PGS).
A single euploid blastocyst was transferred in groups RIF-PGS and NO RIF PGS.
Array CGH was not performed in group RIF NO PGS in which 1-2 blastocysts were transferred.
One monoembryonic sac with heartbeat was found in 28 patients of group RIF PGS and 31 patients of group NO RIF PGS showing similar clinical pregnancy and implantation rates (68.3% and 70.5%, resp.).
In contrast, an embryonic sac with heartbeat was only detected in 7 (21.2%) patients of group RIF NO PGS.
In conclusion, PGS by array CGH with single euploid blastocyst transfer appears to be a successful strategy for patients with multiple failed IVF attempts.
American Psychological Association (APA)
Greco, Ermanno& Bono, Sara& Ruberti, Alessandra& Lobascio, Anna Maria& Greco, Pierfrancesco& Biricik, Anil…[et al.]. 2014. Comparative Genomic Hybridization Selection of Blastocysts for Repeated Implantation Failure Treatment : A Pilot Study. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-473077
Modern Language Association (MLA)
Greco, Ermanno…[et al.]. Comparative Genomic Hybridization Selection of Blastocysts for Repeated Implantation Failure Treatment : A Pilot Study. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-473077
American Medical Association (AMA)
Greco, Ermanno& Bono, Sara& Ruberti, Alessandra& Lobascio, Anna Maria& Greco, Pierfrancesco& Biricik, Anil…[et al.]. Comparative Genomic Hybridization Selection of Blastocysts for Repeated Implantation Failure Treatment : A Pilot Study. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-473077
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473077