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Mechanisms of L-Triiodothyronine-Induced Inhibition of Synaptosomal Na+-K+-ATPase Activity in Young Adult Rat Brain Cerebral Cortex
Joint Authors
Martin, Joseph V.
Ray, Arun K.
Sarkar, Pradip K.
Biswas, Avijit
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The role of thyroid hormones (TH) in the normal functioning of adult mammalian brain is unclear.
Our studies have identified synaptosomal Na+-K+-ATPase as a TH-responsive physiological parameter in adult rat cerebral cortex.
L-triiodothyronine (T3) and L-thyroxine (T4) both inhibited Na+-K+-ATPase activity (but not Mg2+-ATPase activity) in similar dose-dependent fashions, while other metabolites of TH were less effective.
Although both T3 and the β-adrenergic agonist isoproterenol inhibited Na+-K+-ATPase activity in cerebrocortical synaptosomes in similar ways, the β-adrenergic receptor blocker propranolol did not counteract the effect of T3.
Instead, propranolol further inhibited Na+-K+-ATPase activity in a dose-dependent manner, suggesting that the effect of T3 on synaptosomal Na+-K+-ATPase activity was independent of β-adrenergic receptor activation.
The effect of T3 on synaptosomal Na+-K+-ATPase activity was inhibited by the α2-adrenergic agonist clonidine and by glutamate.
Notably, both clonidine and glutamate activate Gi-proteins of the membrane second messenger system, suggesting a potential mechanism for the inhibition of the effects of TH.
In this paper, we provide support for a nongenomic mechanism of action of TH in a neuronal membrane-related energy-linked process for signal transduction in the adult condition.
American Psychological Association (APA)
Sarkar, Pradip K.& Biswas, Avijit& Ray, Arun K.& Martin, Joseph V.. 2013. Mechanisms of L-Triiodothyronine-Induced Inhibition of Synaptosomal Na+-K+-ATPase Activity in Young Adult Rat Brain Cerebral Cortex. Journal of Thyroid Research،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-473082
Modern Language Association (MLA)
Sarkar, Pradip K.…[et al.]. Mechanisms of L-Triiodothyronine-Induced Inhibition of Synaptosomal Na+-K+-ATPase Activity in Young Adult Rat Brain Cerebral Cortex. Journal of Thyroid Research No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-473082
American Medical Association (AMA)
Sarkar, Pradip K.& Biswas, Avijit& Ray, Arun K.& Martin, Joseph V.. Mechanisms of L-Triiodothyronine-Induced Inhibition of Synaptosomal Na+-K+-ATPase Activity in Young Adult Rat Brain Cerebral Cortex. Journal of Thyroid Research. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-473082
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473082