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High-Dose Subcutaneous Immunoglobulins for the Treatment of Severe Treatment-Resistant Polymyositis
Joint Authors
Patrick, Cherin
Jean-Charles, Crave
Jean-Christophe, Delain
Odile, Cartry
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-16
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Polymyositis is a rare debilitating condition characterized by chronic inflammation and muscle weakness.
Standard treatments include corticosteroids and immunosuppressants; however, resistance to these regimens may develop.
Intravenous immunoglobulins (IVIg) are thus recommended for patients with drug-resistant polymyositis.
The patient presented a resistant polymyositis with severe muscle weakness, increasing dysphagia, and significant loss in weight.
Subcutaneous immunoglobulins (SCIg) were initiated after failure of steroids and immunosuppressive drugs.
SCIg was given twice per week (2 then 1.3 g/kg/month).
Clinical recovery was observed within 2 months after the SCIg initiation.
After several injections, the patient showed a progressive improvement in muscle strength.
Serum creatine kinase activity decreased to normal levels, and dysphagia was resolved.
The SC injections were generally well tolerated and good patient satisfaction was reported.
This promising observation suggests that SCIg may be useful in active and refractory polymyositis.
American Psychological Association (APA)
Patrick, Cherin& Jean-Christophe, Delain& Jean-Charles, Crave& Odile, Cartry. 2014. High-Dose Subcutaneous Immunoglobulins for the Treatment of Severe Treatment-Resistant Polymyositis. Case Reports in Rheumatology،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-473109
Modern Language Association (MLA)
Patrick, Cherin…[et al.]. High-Dose Subcutaneous Immunoglobulins for the Treatment of Severe Treatment-Resistant Polymyositis. Case Reports in Rheumatology No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-473109
American Medical Association (AMA)
Patrick, Cherin& Jean-Christophe, Delain& Jean-Charles, Crave& Odile, Cartry. High-Dose Subcutaneous Immunoglobulins for the Treatment of Severe Treatment-Resistant Polymyositis. Case Reports in Rheumatology. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-473109
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473109