Antioncogenic Effects of Transient Receptor Potential Vanilloid 1 in the Progression of Transitional Urothelial Cancer of Human Bladder
Joint Authors
Liberati, Sonia
Santoni, Giorgio
Farfariello, Valerio
Caprodossi, Sara
Amantini, Consuelo
Gismondi, Angela
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The progression of normal cells to a tumorigenic and metastatic state involves the accumulation of mutations in multiple key signaling proteins, encoded by oncogenes and tumor suppressor genes.
Recently, members of the TRP channel family have been included in the oncogenic and tumor suppressor protein family.
TRPM1, TRPM8, and TRPV6 are considered to be tumor suppressors and oncogenes in localized melanoma and prostate cancer, respectively.
Herein, we focus our attention on the antioncogenic properties of TRPV1.
Changes in TRPV1 expression occur during the development of transitional cell carcinoma (TCC) of human bladder.
A progressive decrease in TRPV1 expression as the TCC stage increases triggers the development of a more aggressive gene phenotype and invasiveness.
Finally, downregulation of TRPV1 represents a negative prognostic factor in TCC patients.
The knowledge of the mechanism controlling TRPV1 expression might improve the diagnosis and new therapeutic strategies in bladder cancer.
American Psychological Association (APA)
Santoni, Giorgio& Caprodossi, Sara& Farfariello, Valerio& Liberati, Sonia& Gismondi, Angela& Amantini, Consuelo. 2012. Antioncogenic Effects of Transient Receptor Potential Vanilloid 1 in the Progression of Transitional Urothelial Cancer of Human Bladder. ISRN Urology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-473110
Modern Language Association (MLA)
Santoni, Giorgio…[et al.]. Antioncogenic Effects of Transient Receptor Potential Vanilloid 1 in the Progression of Transitional Urothelial Cancer of Human Bladder. ISRN Urology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-473110
American Medical Association (AMA)
Santoni, Giorgio& Caprodossi, Sara& Farfariello, Valerio& Liberati, Sonia& Gismondi, Angela& Amantini, Consuelo. Antioncogenic Effects of Transient Receptor Potential Vanilloid 1 in the Progression of Transitional Urothelial Cancer of Human Bladder. ISRN Urology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-473110
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473110