Therapeutic Targeting of Redox Signaling in Myofibroblast Differentiation and Age-Related Fibrotic Disease
Joint Authors
Zenzmaier, Christoph
Sampson, Natalie
Berger, Peter
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-22
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Myofibroblast activation plays a central role during normal wound healing.
Whereas insufficient myofibroblast activation impairs wound healing, excessive myofibroblast activation promotes fibrosis in diverse tissues (including benign prostatic hyperplasia, BPH) leading to organ dysfunction and also promotes a stromal response that supports tumor progression.
The incidence of impaired wound healing, tissue fibrosis, BPH, and certain cancers strongly increases with age.
This paper summarizes findings from in vitro fibroblast-to-myofibroblast differentiation systems that serve as cellular models to study fibrogenesis of diverse tissues.
Supported by substantial in vivo data, a large body of evidence indicates that myofibroblast differentiation induced by the profibrotic cytokine transforming growth factor beta is driven by a prooxidant shift in redox homeostasis due to elevated production of NADPH oxidase 4 (NOX4)-derived hydrogen peroxide and supported by concomitant decreases in nitric oxide/cGMP signaling and reactive oxygen species (ROS) scavenging enzymes.
Fibroblast-to-myofibroblast differentiation can be inhibited and reversed by restoring redox homeostasis using antioxidants or NOX4 inactivation as well as enhancing nitric oxide/cGMP signaling via activation of soluble guanylyl cyclases or inhibition of phosphodiesterases.
Current evidence indicates the therapeutic potential of targeting the prooxidant shift in redox homeostasis for the treatment of age-related diseases associated with myofibroblast dysregulation.
American Psychological Association (APA)
Sampson, Natalie& Berger, Peter& Zenzmaier, Christoph. 2012. Therapeutic Targeting of Redox Signaling in Myofibroblast Differentiation and Age-Related Fibrotic Disease. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-473113
Modern Language Association (MLA)
Sampson, Natalie…[et al.]. Therapeutic Targeting of Redox Signaling in Myofibroblast Differentiation and Age-Related Fibrotic Disease. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-473113
American Medical Association (AMA)
Sampson, Natalie& Berger, Peter& Zenzmaier, Christoph. Therapeutic Targeting of Redox Signaling in Myofibroblast Differentiation and Age-Related Fibrotic Disease. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-473113
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473113