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SOD1 Transcriptional and Posttranscriptional Regulation and Its Potential Implications in ALS
Joint Authors
Cova, Emanuela
Cereda, Cristina
Milani, Pamela
Gagliardi, Stella
Source
Neurology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Copper-zinc superoxide dismutase (SOD1) is a detoxifying enzyme localized in the cytosol, nucleus, peroxisomes, and mitochondria.
The discovery that mutations in SOD1 gene cause a subset of familial amyotrophic lateral sclerosis (FALS) has attracted great attention, and studies to date have been mainly focused on discovering mutations in the coding region and investigation at protein level.
Considering that changes in SOD1 mRNA levels have been associated with sporadic ALS (SALS), a molecular understanding of the processes involved in the regulation of SOD1 gene expression could not only unravel novel regulatory pathways that may govern cellular phenotypes and changes in diseases but also might reveal therapeutic targets and treatments.
This review seeks to provide an overview of SOD1 gene structure and of the processes through which SOD1 transcription is controlled.
Furthermore, we emphasize the importance to focus future researches on investigating posttranscriptional mechanisms and their relevance to ALS.
American Psychological Association (APA)
Milani, Pamela& Gagliardi, Stella& Cova, Emanuela& Cereda, Cristina. 2011. SOD1 Transcriptional and Posttranscriptional Regulation and Its Potential Implications in ALS. Neurology Research International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-473127
Modern Language Association (MLA)
Milani, Pamela…[et al.]. SOD1 Transcriptional and Posttranscriptional Regulation and Its Potential Implications in ALS. Neurology Research International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-473127
American Medical Association (AMA)
Milani, Pamela& Gagliardi, Stella& Cova, Emanuela& Cereda, Cristina. SOD1 Transcriptional and Posttranscriptional Regulation and Its Potential Implications in ALS. Neurology Research International. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-473127
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473127