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Histone Deacetylase Inhibitor Therapy in Epithelial Ovarian Cancer
Joint Authors
Takai, Noriyuki
Narahara, Hisashi
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Since epigenetic alterations are believed to be involved in the repression of tumor suppressor genes and promotion of tumorigenesis in ovarian cancers, novel compounds endowed with a histone deacetylase (HDAC) inhibitory activity are an attractive therapeutic approach.
In this review, we discuss the biologic and therapeutic effects of HDAC inhibitors (HDACIs) in treating ovarian cancer.
HDACIs were able to mediate inhibition of cell growth, cell cycle arrest, apoptosis, and expression of genes related to the malignant phenotype in a variety of ovarian cancer cell lines.
Furthermore, HDACIs were able to induce the accumulation of acetylated histones in the chromatin of the p21WAF1 gene in human ovarian carcinoma cells.
In xenograft models, some of HDACIs have demonstrated antitumor activity with only few side effects.
Some clinical trials demonstrate that HDACI drugs provide an important class of new mechanism-based therapeutics for ovarian cancer.
In this review, we discuss the biologic and therapeutic effects of HDACIs in treating ovarian cancer, especially focusing on preclinical studies and clinical trials.
American Psychological Association (APA)
Takai, Noriyuki& Narahara, Hisashi. 2009. Histone Deacetylase Inhibitor Therapy in Epithelial Ovarian Cancer. Journal of Oncology،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-473128
Modern Language Association (MLA)
Takai, Noriyuki& Narahara, Hisashi. Histone Deacetylase Inhibitor Therapy in Epithelial Ovarian Cancer. Journal of Oncology No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-473128
American Medical Association (AMA)
Takai, Noriyuki& Narahara, Hisashi. Histone Deacetylase Inhibitor Therapy in Epithelial Ovarian Cancer. Journal of Oncology. 2009. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-473128
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473128