Partial Chemical Characterization of Immunomodulatory Polysaccharides from Plantago palmata Hook. f. s. Leaves
Joint Authors
Duez, Pierre
Samuelsen, Anne Berit
Vray, Bernard
Biringanine, Gabriel
Ouedraogo, Moustapha
Source
International Journal of Carbohydrate Chemistry
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A previous work on Plantago palmata polysaccharides (PS) attributed immunomodulatory properties of leaves to a polysaccharide fraction (PS50) that stimulated NO and TNF-α production by interferon gamma- (IFN-γ-) activated macrophages.
The present work aims to elucidate the chemical structure of these immunomodulatory polysaccharides.
Size exclusion chromatography showed that the active polymers present an active fraction with a very high molecular weight (about 1200 kDa).
These polysaccharides are pectic in nature, with a predominantly unbranched galacturonan domain and with a domain bearing side chains that consist of highly branched arabinan, galactan, and/or arabinogalactan.
Comparatively to the well-known Plantago major biologically active PS, Plantago palmata PS50 contained less arabinogalactan-proteins (AGPs) and had a different composition in glucose, galactose, and galacturonic acid.
DNA contamination of the polysaccharide was estimated at about 0.04%, a concentration much lower than those reported immunomodulatory in hyaluronic acid preparations (3 to 15%).
Therefore, the eventuality of a contaminating DNA-mediated biological activity could be ruled out.
American Psychological Association (APA)
Biringanine, Gabriel& Ouedraogo, Moustapha& Vray, Bernard& Samuelsen, Anne Berit& Duez, Pierre. 2012. Partial Chemical Characterization of Immunomodulatory Polysaccharides from Plantago palmata Hook. f. s. Leaves. International Journal of Carbohydrate Chemistry،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-473129
Modern Language Association (MLA)
Biringanine, Gabriel…[et al.]. Partial Chemical Characterization of Immunomodulatory Polysaccharides from Plantago palmata Hook. f. s. Leaves. International Journal of Carbohydrate Chemistry No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-473129
American Medical Association (AMA)
Biringanine, Gabriel& Ouedraogo, Moustapha& Vray, Bernard& Samuelsen, Anne Berit& Duez, Pierre. Partial Chemical Characterization of Immunomodulatory Polysaccharides from Plantago palmata Hook. f. s. Leaves. International Journal of Carbohydrate Chemistry. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-473129
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473129