Encapsulation of Liposomes within pH Responsive Microspheres for Oral Colonic Drug Delivery
Joint Authors
Barea, M. J.
Lee, Y. S.
Bridson, R. H.
Jenkins, M. J.
Johnson, P.
Source
International Journal of Biomaterials
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A novel liposome-in-microsphere (LIM) formulation has been created comprising drug-loaded liposomes within pH responsive Eudragit S100 microspheres.
The liposomes contained the model drug 5-ASA and were coated with chitosan in order to protect them during encapsulation within the microspheres and to improve site-specific release characteristics.
In vitro drug release studies showed that LIMs prevented drug release within simulated stomach and small intestine conditions with subsequent drug release occurring in large intestine conditions.
The formulation therefore has potential for oral colonic drug delivery.
American Psychological Association (APA)
Barea, M. J.& Jenkins, M. J.& Lee, Y. S.& Johnson, P.& Bridson, R. H.. 2012. Encapsulation of Liposomes within pH Responsive Microspheres for Oral Colonic Drug Delivery. International Journal of Biomaterials،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-473150
Modern Language Association (MLA)
Barea, M. J.…[et al.]. Encapsulation of Liposomes within pH Responsive Microspheres for Oral Colonic Drug Delivery. International Journal of Biomaterials No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-473150
American Medical Association (AMA)
Barea, M. J.& Jenkins, M. J.& Lee, Y. S.& Johnson, P.& Bridson, R. H.. Encapsulation of Liposomes within pH Responsive Microspheres for Oral Colonic Drug Delivery. International Journal of Biomaterials. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-473150
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473150
