The Role of −786TC Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic Syndrome
Joint Authors
Misiak, Blazej
Krolik, Marta
Leszczynski, Przemyslaw
Slezak, Ryszard
Stankiewicz-Olczyk, Joanna
Lewera, Anna
Kukowka, Anna
Source
International Journal of Endocrinology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Extensive evidence, arising from models of endothelial nitric oxide synthase gene (NOS3)-knockout mice supports the role of endothelial malfunction in the pathogenesis of the metabolic syndrome (MS).
Aims.
The aim of this study was to evaluate the role of −786T/C polymorphism in the etiology of MS and assess previously reported interaction with cigarette smoking.
Methods.
Based on International Diabetes Federation 2005 criteria, we recruited randomly 152 subjects with MS and 75 subjects without MS.
Results.
Allelic and genotype frequencies did not differ significantly between both groups.
Total cholesterol level (CHOLT) and intima-media thickness of carotid arteries were significantly higher in −786CC homozygotes, in comparison with −786TC and −786TT patients.
Regarding current smoking status, −786C allele was associated with higher CHOLT than −786T allele.
Conclusion.
Our study indicates the putative role of −786T/C polymorphism in the development of hypercholesterolemia, in patients with MS, which might be enhanced by cigarette smoking.
American Psychological Association (APA)
Misiak, Blazej& Krolik, Marta& Kukowka, Anna& Lewera, Anna& Leszczynski, Przemyslaw& Stankiewicz-Olczyk, Joanna…[et al.]. 2011. The Role of −786TC Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic Syndrome. International Journal of Endocrinology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-473158
Modern Language Association (MLA)
Misiak, Blazej…[et al.]. The Role of −786TC Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic Syndrome. International Journal of Endocrinology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-473158
American Medical Association (AMA)
Misiak, Blazej& Krolik, Marta& Kukowka, Anna& Lewera, Anna& Leszczynski, Przemyslaw& Stankiewicz-Olczyk, Joanna…[et al.]. The Role of −786TC Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic Syndrome. International Journal of Endocrinology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-473158
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473158