![](/images/graphics-bg.png)
Autologous Blood Transfusion after Local Infiltration Analgesia with Ropivacaine in Total Knee and Hip Arthroplasty
Joint Authors
Hindersson, Peter
Brouw Jørgensen, Mogens
Brødsgaard Dencker, Bjarne
Simonsen, Ole
Breindahl, Torben
Rasmussen, Sten
Source
Anesthesiology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aims.
To study the safety of autotransfusion following local infiltration analgesia (LIA) with ropivacaine.
Background.
Knowledge of blood concentrations of ropivacaine after LIA and autotransfusion is crucial.
However, very limited data are available for toxicological risk assessment.
Methods.
Autotransfusion was studied in patients after total knee arthroplasty (TKA: n=25) and total hip arthroplasty (THA: n=27) with LIA using 200 mg ropivacaine, supplemented with two postoperative bolus injections (150 mg ropivacaine).
Drainage blood was reinfused within 6 h postoperatively.
Results.
Reinfusion caused a significant increase in the serum concentration of total ropivacaine for TKA from 0.54±0.17 (mean ± SD) to 0.79±0.20 μg/mL (P<0.001) and a nonsignificant increase for THA from 0.62±0.17 to 0.63±0.18 μg/mL.
The maximum free (unbound) concentration after reinfusion was 0.038 μg/mL.
Peak total and free venous ropivacaine concentrations after 8 h and 16 h postoperative bolus injections were 2.6 μg/mL and 0.11 μg/mL, respectively.
All concentrations observed were below the threshold for toxicity and no side effects were observed.
Conclusion.
Autotransfusion of patients undergoing knee or hip arthroplasty after local infiltration analgesia with 200 mg ropivacaine can be performed safely, even supplemented with 8 h and 16 h postoperative bolus injections.
American Psychological Association (APA)
Breindahl, Torben& Simonsen, Ole& Hindersson, Peter& Brødsgaard Dencker, Bjarne& Brouw Jørgensen, Mogens& Rasmussen, Sten. 2012. Autologous Blood Transfusion after Local Infiltration Analgesia with Ropivacaine in Total Knee and Hip Arthroplasty. Anesthesiology Research and Practice،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-473161
Modern Language Association (MLA)
Breindahl, Torben…[et al.]. Autologous Blood Transfusion after Local Infiltration Analgesia with Ropivacaine in Total Knee and Hip Arthroplasty. Anesthesiology Research and Practice No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-473161
American Medical Association (AMA)
Breindahl, Torben& Simonsen, Ole& Hindersson, Peter& Brødsgaard Dencker, Bjarne& Brouw Jørgensen, Mogens& Rasmussen, Sten. Autologous Blood Transfusion after Local Infiltration Analgesia with Ropivacaine in Total Knee and Hip Arthroplasty. Anesthesiology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-473161
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473161