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Serum Anticholinergic Activity : A Possible Peripheral Marker of the Anticholinergic Burden in the Central Nervous System in Alzheimer’s Disease
Joint Authors
Azuma, Kazunari
Hori, Koji
Hosoi, Misa
Konishi, Kimiko
Akita, Ryo
Akashi, Norihisa
Kitajima, Yuka
Ikuse, Daisuke
Jinbo, Koichi
Hachisu, Mitsugu
Tomioka, Hiroi
Tani, Masayuki
Yokoyama, Sachiko
Aoki, Mari
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We review the utility of serum anticholinergic activity (SAA) as a peripheral marker of anticholinergic activity (AA) in the central nervous system (CAA).
We hypothesize that the compensatory mechanisms of the cholinergic system do not contribute to SAA if their system is intact and that if central cholinergic system deteriorates alone in conditions such as Alzheimer’s disease or Lewy body dementia, CAA and SAA are caused by way of hyperactivity of inflammatory system and SAA is a marker of the anticholinergic burden in CNS.
Taking into account the diurnal variations in the plasma levels of corticosteroids, which are thought to affect SAA, it should be measured at noon or just afterward.
American Psychological Association (APA)
Hori, Koji& Konishi, Kimiko& Tani, Masayuki& Tomioka, Hiroi& Akita, Ryo& Kitajima, Yuka…[et al.]. 2014. Serum Anticholinergic Activity : A Possible Peripheral Marker of the Anticholinergic Burden in the Central Nervous System in Alzheimer’s Disease. Disease Markers،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-473171
Modern Language Association (MLA)
Hori, Koji…[et al.]. Serum Anticholinergic Activity : A Possible Peripheral Marker of the Anticholinergic Burden in the Central Nervous System in Alzheimer’s Disease. Disease Markers No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-473171
American Medical Association (AMA)
Hori, Koji& Konishi, Kimiko& Tani, Masayuki& Tomioka, Hiroi& Akita, Ryo& Kitajima, Yuka…[et al.]. Serum Anticholinergic Activity : A Possible Peripheral Marker of the Anticholinergic Burden in the Central Nervous System in Alzheimer’s Disease. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-473171
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473171