Intraductal Papillary Neoplasms of the Bile Duct

Joint Authors

Yokosuka, Osamu
Yoshitomi, Hideyuki
Miyazaki, Masaru
Tsuyuguchi, Toshio
Ohtsuka, Masayuki
Sakai, Yuji
Furukawa, Katsunori
Shimizu, Hiroaki
Kato, Atsushi

Source

International Journal of Hepatology

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-05-18

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Medicine

Abstract EN

Intraductal papillary neoplasm of the bile duct (IPNB) is a rare variant of bile duct tumors characterized by papillary growth within the bile duct lumen and is regarded as a biliary counterpart of intraductal papillary mucinous neoplasm of the pancreas.

IPNBs display a spectrum of premalignant lesion towards invasive cholangiocarcinoma.

The most common radiologic findings for IPNB are bile duct dilatation and intraductal masses.

The major treatment of IPNB is surgical resection.

Ultrasonography, computed tomography, magnetic resonance image, and cholangiography are usually performed to assess tumor location and extension.

Cholangioscopy can confirm the histology and assess the extent of the tumor including superficial spreading along the biliary epithelium.

However, pathologic diagnosis by preoperative biopsy cannot always reflect the maximum degree of atypia, because IPNBs are often composed of varying degrees of cytoarchitectural atypia.

IPNBs are microscopically classified into four epithelial subtypes, such as pancreatobiliary, intestinal, gastric, and oncocytic types.

Most cases of IPNB are IPN with high-grade intraepithelial neoplasia or with an associated invasive carcinoma.

The histologic types of invasive lesions are either tubular adenocarcinoma or mucinous carcinoma.

Although several authors have investigated molecular genetic changes during the development and progression of IPNB, these are still poorly characterized and controversial.

American Psychological Association (APA)

Ohtsuka, Masayuki& Shimizu, Hiroaki& Kato, Atsushi& Yoshitomi, Hideyuki& Furukawa, Katsunori& Tsuyuguchi, Toshio…[et al.]. 2014. Intraductal Papillary Neoplasms of the Bile Duct. International Journal of Hepatology،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-473182

Modern Language Association (MLA)

Ohtsuka, Masayuki…[et al.]. Intraductal Papillary Neoplasms of the Bile Duct. International Journal of Hepatology No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-473182

American Medical Association (AMA)

Ohtsuka, Masayuki& Shimizu, Hiroaki& Kato, Atsushi& Yoshitomi, Hideyuki& Furukawa, Katsunori& Tsuyuguchi, Toshio…[et al.]. Intraductal Papillary Neoplasms of the Bile Duct. International Journal of Hepatology. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-473182

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-473182