Weight Gain, Schizophrenia and Antipsychotics : New Findings from Animal Model and Pharmacogenomic Studies
Joint Authors
Panariello, Fabio
De Luca, Vincenzo
de Bartolomeis, Andrea
Source
Schizophrenia Research and Treatment
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-06
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Excess body weight is one of the most common physical health problems among patients with schizophrenia that increases the risk for many medical problems, including type 2 diabetes mellitus, coronary heart disease, osteoarthritis, and hypertension, and accounts in part for 20% shorter life expectancy than in general population.
Among patients with severe mental illness, obesity can be attributed to an unhealthy lifestyle, personal genetic profile, as well as the effects of psychotropic medications, above all antipsychotic drugs.
Novel “atypical” antipsychotic drugs represent a substantial improvement on older “typical” drugs.
However, clinical experience has shown that some, but not all, of these drugs can induce substantial weight gain.
Animal models of antipsychotic-related weight gain and animal transgenic models of knockout or overexpressed genes of antipsychotic receptors have been largely evaluated by scientific community for changes in obesity-related gene expression or phenotypes.
Moreover, pharmacogenomic approaches have allowed to detect more than 300 possible candidate genes for antipsychotics-induced body weight gain.
In this paper, we summarize current thinking on: (1) the role of polymorphisms in several candidate genes, (2) the possible roles of various neurotransmitters and neuropeptides in this adverse drug reaction, and (3) the state of development of animal models in this matter.
We also outline major areas for future research.
American Psychological Association (APA)
Panariello, Fabio& De Luca, Vincenzo& de Bartolomeis, Andrea. 2010. Weight Gain, Schizophrenia and Antipsychotics : New Findings from Animal Model and Pharmacogenomic Studies. Schizophrenia Research and Treatment،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-473205
Modern Language Association (MLA)
Panariello, Fabio…[et al.]. Weight Gain, Schizophrenia and Antipsychotics : New Findings from Animal Model and Pharmacogenomic Studies. Schizophrenia Research and Treatment No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-473205
American Medical Association (AMA)
Panariello, Fabio& De Luca, Vincenzo& de Bartolomeis, Andrea. Weight Gain, Schizophrenia and Antipsychotics : New Findings from Animal Model and Pharmacogenomic Studies. Schizophrenia Research and Treatment. 2010. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-473205
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473205