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Distribution, Size, and Shape of Abdominal Aortic Calcified Deposits and Their Relationship to Mortality in Postmenopausal Women
Joint Authors
Ganz, Melanie
de Bruijne, Marleen
Karsdal, Morten A.
Christiansen, Claus
Dam, Erik B.
Pettersen, Paola
Nielsen, Mads
Source
International Journal of Biomedical Imaging
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Abdominal aortic calcifications (AACs) correlate strongly with coronary artery calcifications and can be predictors of cardiovascular mortality.
We investigated whether size, shape, and distribution of AACs are related to mortality and how such prognostic markers perform compared to the state-of-the-art AC24 marker introduced by Kauppila.
Methods.
For 308 postmenopausal women, we quantified the number of AAC and the percentage of the abdominal aorta that the lesions occupied in terms of their area, simulated plaque area, thickness, wall coverage, and length.
We analysed inter-/intraobserver reproducibility and predictive ability of mortality after 8-9 years via Cox regression leading to hazard ratios (HRs).
Results.
The coefficient of variation was below 25% for all markers.
The strongest individual predictors were the number of calcifications (HR=2.4) and the simulated area percentage (HR=2.96) of a calcified plaque, and, unlike AC24 (HR=1.66), they allowed mortality prediction also after adjusting for traditional risk factors.
In a combined Cox regression model, the strongest complementary predictors were the number of calcifications (HR=2.76) and the area percentage (HR=−3.84).
Conclusion.
Morphometric markers of AAC quantified from radiographs may be a useful tool for screening and monitoring risk of CVD mortality.
American Psychological Association (APA)
Ganz, Melanie& de Bruijne, Marleen& Dam, Erik B.& Pettersen, Paola& Karsdal, Morten A.& Christiansen, Claus…[et al.]. 2012. Distribution, Size, and Shape of Abdominal Aortic Calcified Deposits and Their Relationship to Mortality in Postmenopausal Women. International Journal of Biomedical Imaging،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-473206
Modern Language Association (MLA)
Ganz, Melanie…[et al.]. Distribution, Size, and Shape of Abdominal Aortic Calcified Deposits and Their Relationship to Mortality in Postmenopausal Women. International Journal of Biomedical Imaging No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-473206
American Medical Association (AMA)
Ganz, Melanie& de Bruijne, Marleen& Dam, Erik B.& Pettersen, Paola& Karsdal, Morten A.& Christiansen, Claus…[et al.]. Distribution, Size, and Shape of Abdominal Aortic Calcified Deposits and Their Relationship to Mortality in Postmenopausal Women. International Journal of Biomedical Imaging. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-473206
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473206