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Increased Release Time of Antibiotics from Bone Allografts through a Novel Biodegradable Coating
Joint Authors
Szendrői, Miklós
Hornyák, István
Vácz, Gabriella
Han, Weiping
Horváthy, Dénes B.
Madácsi, Edit
Lacza, Zsombor
Kalugyer, Pálma
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The use of bone allografts is contraindicated in septic revision surgery due to the high risk of graft reinfection.
Antibiotic release from the graft may solve the problem and these combinations can theoretically be used for prevention or even therapy of infection.
The present study investigated whether amoxicillin, ciprofloxacin, and vancomycin alone or in combination with chitosan or alginate are suitable for short-term or long-term bone coating.
Human bone allografts were prepared from femoral head and lyophilized.
Antibiotic coating was achieved by incubating the grafts in antibiotic solution and freeze-drying again.
Two biopolymers chitosan and alginate were used for creating sustained-release implantable coatings and the drug release profile was characterized in vitro by spectrophotometry.
Using lyophilization with or without chitosan only resulted in short-term release that lasted up to 48 hours.
Alginate coating enabled a sustained release that lasted for 8 days with amoxicillin, 28 days with ciprofloxacin coating, and 50 days with vancomycin coating.
Using only implantable biodegradable allograft and polymers, a sustained release of antibiotics was achieved with ciprofloxacin and vancomycin for several weeks.
Since the calculated daily release of the antibiotic was lower than the recommended IV dose, the calcium alginate coated bone graft can support endoprosthesis revision surgery.
American Psychological Association (APA)
Hornyák, István& Madácsi, Edit& Kalugyer, Pálma& Vácz, Gabriella& Horváthy, Dénes B.& Szendrői, Miklós…[et al.]. 2014. Increased Release Time of Antibiotics from Bone Allografts through a Novel Biodegradable Coating. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-473270
Modern Language Association (MLA)
Hornyák, István…[et al.]. Increased Release Time of Antibiotics from Bone Allografts through a Novel Biodegradable Coating. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-473270
American Medical Association (AMA)
Hornyák, István& Madácsi, Edit& Kalugyer, Pálma& Vácz, Gabriella& Horváthy, Dénes B.& Szendrői, Miklós…[et al.]. Increased Release Time of Antibiotics from Bone Allografts through a Novel Biodegradable Coating. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-473270
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473270