SOST and DKK : Antagonists of LRP Family Signaling as Targets for Treating Bone Disease
Joint Authors
Mason, James J.
Williams, Bart O.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The study of rare human genetic disorders has often led to some of the most significant advances in biomedical research.
One such example was the body of work that resulted in the identification of the Low Density Lipoprotein-Related Protein (LRP5) as a key regulator of bone mass.
Point mutations were identified that encoded forms of LRP5 associated with very high bone mass (HBM).
HBM patients live to a normal age and do not appear to have increased susceptibility to carcinogenesis or other disease.
Thus, devising methods to mimic the molecular consequences of this mutation to treat bone diseases associated with low bone mass is a promising avenue to pursue.
Two groups of agents related to putative LRP5/6 functions are under development.
One group, the focus of this paper, is based on antagonizing the functions of putative inhibitors of Wnt signaling, Dickkopf-1 (DKK1), and Sclerostin (SOST).
Another group of reagents under development is based on the observation that LRP5 may function to control bone mass by regulating the secretion of serotonin from the enterrochromaffin cells of the duodenum.
American Psychological Association (APA)
Mason, James J.& Williams, Bart O.. 2010. SOST and DKK : Antagonists of LRP Family Signaling as Targets for Treating Bone Disease. Journal of Osteoporosis،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-473272
Modern Language Association (MLA)
Mason, James J.& Williams, Bart O.. SOST and DKK : Antagonists of LRP Family Signaling as Targets for Treating Bone Disease. Journal of Osteoporosis No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-473272
American Medical Association (AMA)
Mason, James J.& Williams, Bart O.. SOST and DKK : Antagonists of LRP Family Signaling as Targets for Treating Bone Disease. Journal of Osteoporosis. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-473272
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473272