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All-Cause Mortality Risk of Metabolically Healthy Obese Individuals in NHANES III
Joint Authors
Durward, C. M.
Hartman, Terryl
Nickols-Richardson, S. M.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Mortality risk across metabolic health-by-BMI categories in NHANES-III was examined.
Metabolic health was defined as: (1) homeostasis model assessment-insulin resistance (HOMA-IR) <2.5; (2) ≤2 Adult Treatment Panel (ATP) III metabolic syndrome criteria; (3) combined definition using ≤1 of the following: HOMA-IR ≥1.95 (or diabetes medications), triglycerides ≥1.7 mmol/L, HDL-C <1.04 mmol/L (males) or <1.30 mmol/L (females), LDL-C ≥2.6 mmol/L, and total cholesterol ≥5.2 mmol/L (or cholesterol-lowering medications).
Hazard ratios (HR) for all-cause mortality were estimated with Cox regression models.
Nonpregnant women and men were included (n=4373, mean ± SD, age 37.1±10.9 years, BMI 27.3±5.8 kg/m2, 49.4% female).
Only 40 of 1160 obese individuals were identified as MHO by all definitions.
MHO groups had superior levels of clinical risk factors compared to unhealthy individuals but inferior levels compared to healthy lean groups.
There was increased risk of all-cause mortality in metabolically unhealthy obese participants regardless of definition (HOMA-IR HR 2.07 (CI 1.3–3.4), P<0.01; ATP-III HR 1.98 (CI 1.4–2.9), P<0.001; combined definition HR 2.19 (CI 1.3–3.8), P<0.01).
MHO participants were not significantly different from healthy lean individuals by any definition.
While MHO individuals are not at significantly increased risk of all-cause mortality, their clinical risk profile is worse than that of metabolically healthy lean individuals.
American Psychological Association (APA)
Durward, C. M.& Hartman, Terryl& Nickols-Richardson, S. M.. 2012. All-Cause Mortality Risk of Metabolically Healthy Obese Individuals in NHANES III. Journal of Obesity،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-473292
Modern Language Association (MLA)
Durward, C. M.…[et al.]. All-Cause Mortality Risk of Metabolically Healthy Obese Individuals in NHANES III. Journal of Obesity No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-473292
American Medical Association (AMA)
Durward, C. M.& Hartman, Terryl& Nickols-Richardson, S. M.. All-Cause Mortality Risk of Metabolically Healthy Obese Individuals in NHANES III. Journal of Obesity. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-473292
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473292