Ketamine Inhibits Lung Fluid Clearance through Reducing Alveolar Sodium Transport
Joint Authors
Ji, Hong-Fang
Wang, Junke
Cui, Yong
Nie, Hongguang
Ma, Hong
Chen, Lei
Zhang, Lin
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Ketamine is a broadly used anaesthetic for analgosedation.
Accumulating clinical evidence shows that ketamine causes pulmonary edema with unknown mechanisms.
We measured the effects of ketamine on alveolar fluid clearance in human lung lobes ex vivo.
Our results showed that intratracheal instillation of ketamine markedly decreased the reabsorption of 5% bovine serum albumin instillate.
In the presence of amiloride (a specific ENaC blocker), fluid resolution was not further decreased, suggesting that ketamine could decrease amiloride-sensitive fraction of AFC associated with ENaC.
Moreover, we measured the regulation of amiloride-sensitive currents by ketamine in A549 cells using whole-cell patch clamp mode.
Our results suggested that ketamine decreased amiloride-sensitive Na+ currents (ENaC activity) in a dose-dependent fashion.
These data demonstrate that reduction in lung ENaC activity and lung fluid clearance following administration of ketamine may be the crucial step of the pathogenesis of resultant pulmonary edema.
American Psychological Association (APA)
Cui, Yong& Nie, Hongguang& Ma, Hong& Chen, Lei& Zhang, Lin& Wang, Junke…[et al.]. 2011. Ketamine Inhibits Lung Fluid Clearance through Reducing Alveolar Sodium Transport. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-473312
Modern Language Association (MLA)
Cui, Yong…[et al.]. Ketamine Inhibits Lung Fluid Clearance through Reducing Alveolar Sodium Transport. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-473312
American Medical Association (AMA)
Cui, Yong& Nie, Hongguang& Ma, Hong& Chen, Lei& Zhang, Lin& Wang, Junke…[et al.]. Ketamine Inhibits Lung Fluid Clearance through Reducing Alveolar Sodium Transport. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-473312
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473312