The Roles of CD73 in Cancer
Joint Authors
Gao, Zhao-wei
Zhang, Hui-zhong
Dong, Ke
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purinergic signaling has emerged as an important player in cancer progression and is regulated by a series of nucleotidases.
Among the enzyme cascade, CD73, which catelyzes AMP breakdown to adenosine, has been found to be overexpressed in many types of cancer.
Various factors and mechanisms are employed to regulate expression of CD73.
Accumulating studies have shown that CD73 is a key regulatory molecule of cancer cells proliferation, migration and invasion in vitro, tumor angiogenesis, and tumor immune escape in vivo.
With such important roles in cancer, CD73 has become an appealing therapy target.
Recent evidences in mice models demonstrated that targeted blockade of CD73 could be a favorable therapeutic approach for cancer patients in the future.
In this review, we will summarize the multiple roles of CD73 in cancer development, including its clinical significance, its promotive effects on tumor growth, metastasis, and angiogenesis, and its suppressive effects on immune response, regulatory mechanisms of CD73 expression, and current situation of anti-CD73 cancer therapy.
American Psychological Association (APA)
Gao, Zhao-wei& Dong, Ke& Zhang, Hui-zhong. 2014. The Roles of CD73 in Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-473319
Modern Language Association (MLA)
Gao, Zhao-wei…[et al.]. The Roles of CD73 in Cancer. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-473319
American Medical Association (AMA)
Gao, Zhao-wei& Dong, Ke& Zhang, Hui-zhong. The Roles of CD73 in Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-473319
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473319