Peroxisome Proliferator-Activated Receptor Agonists : Do They Increase Cardiovascular Risk?
Joint Authors
Aljada, Ahmad
Mousa, Shaker A.
Shah, Kshitij Ashwin
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-08-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Cardiovascular disease is a major cause of morbidity and mortality among people with type 2 diabetes mellitus.
The peroxisome proliferator-activated receptor (PPAR) agonists have a significant role on glucose and fat metabolism.
Thiazolidinediones (TZDs) are predominantly PPARγ agonists, and their primary benefit appears to be the prevention of diabetic complications by improving glycemic control and lipid profile.
Recently, the cardiovascular safety of rosiglitazone was brought to center stage following meta analyses and the interim analysis of the RECORD trial.
Current evidence points to rosiglitazone having a greater risk of myocardial ischemic events than placebo, metformin, or sulfonylureas.
This review article discusses the mechanism of action of PPAR agonists and correlates it with clinical and laboratory outcomes in the published literature.
In addition, this review article attempts to discuss some of the molecular mechanisms regarding the association between TZDs therapy and the nontraditional cardiovascular risks.
American Psychological Association (APA)
Aljada, Ahmad& Shah, Kshitij Ashwin& Mousa, Shaker A.. 2009. Peroxisome Proliferator-Activated Receptor Agonists : Do They Increase Cardiovascular Risk?. PPAR Research،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-473330
Modern Language Association (MLA)
Aljada, Ahmad…[et al.]. Peroxisome Proliferator-Activated Receptor Agonists : Do They Increase Cardiovascular Risk?. PPAR Research No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-473330
American Medical Association (AMA)
Aljada, Ahmad& Shah, Kshitij Ashwin& Mousa, Shaker A.. Peroxisome Proliferator-Activated Receptor Agonists : Do They Increase Cardiovascular Risk?. PPAR Research. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-473330
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473330